127792-49-8

Basic information

• Product Name: 2-BroMo-5-chlorophenylacetonitrile
• Synonyms: 2-BroMo-5-chlorophenylacetonitrile;2-(2-Bromo-5-chlorophenyl)acetonitrile;2-Bromo-5-chlorobenzeneacetonitrile
• CAS NO: 127792-49-8
• Molecular Formula: C₈H₅BrFN
• Molecular Weight: 230.489
• Mol File: 127792-49-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 307.8±27.0 °C(Predicted)
• Appearance: /
• Density: 1.603±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-BroMo-5-chlorophenylacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BroMo-5-chlorophenylacetonitrile(127792-49-8)
• EPA Substance Registry System: 2-BroMo-5-chlorophenylacetonitrile(127792-49-8)

Safety Data

• Hazardous Substances Data: 127792-49-8(Hazardous Substances Data)

Usage

General Description

2-Bromo-5-chlorophenylacetonitrile is a unique organic compound that belongs to the class of organobromine compounds. It has the molecular formula C8H4BrClN. The molecule can be described as a phenylacetonitrile which is bromo- and chloro- substituted at different locations on the phenyl ring. Generally, it's utilised as an intermediate in the synthesis of more complex organic molecules. Proper handling is essential due to its powerful reactivity, as with many organobromine compounds. It has not found significant applications in the pharmaceutical or chemical industry, and so its production is generally confined to laboratory sizing for academic research purposes.

Upstream product

• 151-50-8 potassium cyanide 
• 112399-50-5 2-bromo-5-fluorobenzyl bromide 
• 143-33-9 sodium cyanide 
• 333-20-0 potassium thioacyanate 
• 66192-24-3 2-bromo-5-chlorobenzyl bromide 
• 14495-51-3 2-bromo-5-chlorotoluene 
• 60666-70-8 2-bromo-5-chlorobenzyl alcohol 
• 773837-37-9 sodium cyanide 
• 174265-12-4 2-bromo-5-chlorobenzaldehyde 
• 1529-41-5 3-chloro-benzeneacetonitrile 

Downstream Products

• 127792-50-1 potassium 2-bromo-5-fluorophenylacetate 
• 127792-43-2 sodium {2-[(2,6-dichlorophenyl)amino]-5-fluorophenyl}acetate 
• 127792-42-1 sodium {2-[(2,6-dichloro-4-fluorophenyl)amino]-5-fluorophenyl}acetate 
• 1017581-68-8 [2-(3,4-dimethoxyphenylethynyl)-5-fluorophenyl]acetonitrile 
• 1273546-98-7 (3S)-(E)-N-Boc-N-[2-[2-(3-tert-butyldimethylsilyloxy-1-butenyl)-5-chlorophenyl]ethyl]amine 
• 1273547-07-1 (3S)-(E)-N-Boc-N-[2-[5-chloro-2-(3-hydroxybut-1-enyl)-phenyl]ethyl]amine 
• 1273546-86-3 N-Boc-N-[2-(2-bromo-5-chloro-phenyl)ethyl]amine 
• 1312716-63-4 1-(2-bromo-5-fluorophenyl)cyclohexanecarbaldehyde 
• 1546-10-7 1-cyclohex-1-en-1-yl-3-fluorobenzene 
• 1380541-06-9 2-(2-bromo-5-fluorophenyl)-2-isopropyl-3-methylbutanenitrile 
• 17630-75-0 5-chloro-indolin-2-one 
• 1314790-02-7 2-(2-bromo-5-chlorophenyl)-2-methylpropanenitrile 
• 1379974-95-4 2-(2-bromo-5-chlorophenyl)ethan-1-amine 
• 1422148-82-0 2-(2-bromo-5-chlorophenyl)acetamide 

Relevant articles and documents

Highly diastereoselective synthesis of tetralin-fused spirooxindoles via lewis acid-catalyzed C(sp3)H bond functionalization

A highly diastereoselective synthesis of tetralin-fused spirooxindole derivatives was described. Treatment of benzylidene oxindoles with a catalytic amount of Sc(OTf)3 in refluxing hexane afforded the target compounds in good chemical yields with excellent diastereoselectivities (up to >20:1). Detailed investigation of the reaction mechanism revealed that both interconversion of the two diastereomers and their solubility difference in reaction medium were the key to achieving excellent diastereoselectivities.

AUTOTAXIN INHIBITORS COMPRISING A HETEROAROMATIC RING-BENZYL-AMIDE-CYCLE CORE

The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.

Copper-catalyzed domino coupling reaction: An efficient method to synthesize oxindoles

An efficient and novel procedure for a copper catalyzed domino coupling reaction has been developed, which afforded various oxindoles in good to excellent yields with tolerance of various substituents. In addition, this method could be applied to synthesize horsfiline and coerulescine in few steps with high total yields. The Royal Society of Chemistry 2012.