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1422364-63-3

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1422364-63-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1422364-63-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,2,3,6 and 4 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1422364-63:
(9*1)+(8*4)+(7*2)+(6*2)+(5*3)+(4*6)+(3*4)+(2*6)+(1*3)=133
133 % 10 = 3
So 1422364-63-3 is a valid CAS Registry Number.

1422364-63-3Relevant articles and documents

Novel diaryl ureas with efficacy in a mouse model of malaria

Anderson, John W.,Sarantakis, Dimitri,Terpinski, Jacek,Santha Kumar,Tsai, Han-Chun,Kuo, MacK,Ager, Arba L.,Jacobs Jr., William R.,Schiehser, Guy A.,Ekins, Sean,Sacchettini, James C.,Jacobus, David P.,Fidock, David A.,Freundlich, Joel S.

, p. 1022 - 1025 (2013/03/13)

Exploration of triclosan analogs has led to novel diaryl ureas with significant potency against in vitro cultures of drug-resistant and drug-sensitive strains of the human malaria parasite Plasmodium falciparum. Compound 18 demonstrated EC50 values of 37 and 55 nM versus in vitro cultured parasite strains and promising in vivo efficacy in a Plasmodium berghei antimalarial mouse model, with >50% survival at day 31 post-treatment when administered subcutaneously at 256 mg/kg. This series of compounds provides a chemical scaffold of novel architecture, as validated by cheminformatics analysis, to pursue antimalarial drug discovery efforts.

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