14225-80-0

Basic information

• Product Name: BENZIMIDAZOLE, 2-(2,5-DICHLOROPHENYL)-
• Synonyms: BENZIMIDAZOLE, 2-(2,5-DICHLOROPHENYL)-;2-(2,5-Dichloro-phenyl)-1H-benzoimidazole
• CAS NO: 14225-80-0
• Molecular Formula: C₁₃H₈Cl₂N₂
• Molecular Weight: 263.12
• Mol File: 14225-80-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 458.6°C at 760 mmHg
• Flash Point: 263.6°C
• Appearance: /
• Density: 1.427g/cm³
• Vapor Pressure: 1.36E-08mmHg at 25°C
• Refractive Index: 1.697
• CAS DataBase Reference: BENZIMIDAZOLE, 2-(2,5-DICHLOROPHENYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: BENZIMIDAZOLE, 2-(2,5-DICHLOROPHENYL)-(14225-80-0)
• EPA Substance Registry System: BENZIMIDAZOLE, 2-(2,5-DICHLOROPHENYL)-(14225-80-0)

Safety Data

• Hazardous Substances Data: 14225-80-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H8Cl2N2/c14-8-5-6-10(15)9(7-8)13-16-11-3-1-2-4-12(11)17-13/h1-7H,(H,16,17)

Upstream product

• 34145-05-6 2,5-dichlorobenzyl alcohol 
• 95-54-5 1,2-diamino-benzene 
• 328283-72-3 2,5-dichloro-N-(2-iodophenyl)benzamide 
• 2905-61-5 2,5-dichlorobenzoyl chloride 
• 615-43-0 2-iodophenylamine 
• 50-79-3 2,5-dichlorobenzoic acid 

Downstream Products

• 1602748-14-0 methyl 2-(2-(2,5-dichlorophenyl)-1H-benzo[d]imidazol-1-yl)acetate 

Relevant articles and documents

Visible-Light Photoredox Catalyzed Double C-H Functionalization: Radical Cascade Cyclization of Ethers with Benzimidazole-Based Cyanamides

A visible-light photoredox catalyzed radical cascade cyclization of simple ethers with cyanamides is developed at room temperature. This strategy involves sequential inert Csp3-H/Csp2-H functionalizations through intermolecular addition reaction of oxyalkyl radicals to N-cyano groups followed by radical cyclization of iminyl radicals in situ generated with C-2 aryl rings. This method allows for efficient synthesis of tetracyclic benzo[4,5]imidazo[1,2-c]quinazolines. Importantly, this is the first example of an intermolecular-intramolecular radical cascade cyclization reaction of cyanamides.

BENZIMIDAZOLE DERIVATIVES AS MITOCHONDRIAL FUNCTION MODULATORS

Provided are a benzimidazole derivative modulating mitochondrial functions and having pharmaceutical activity as a neuro-protective agent, and a pharmaceutical composition including the compound as an active ingredient.