1422736-37-5Relevant articles and documents
Selective O-difluoromethylation of 1,3-diones by bromodifluoromethylating reagents
Liu, Guokai,Wang, Xin,Xu, Xiu-Hua,Lu, Xu,Tokunaga, Etsuko,Tsuzuki, Seiji,Shibata, Norio
, p. 1044 - 1047 (2013)
The regioselective O-difluoromethylation of 1,3-diones was achieved via in situ generation of difluorocarbene from bromodifluoromethylating reagents in the presence of an organic base. A wide variety of difluormethyl enol ethers were obtained in good to excellent yields. The reaction mechanism is discussed based on ab initio calculations (kcal/mol).