142326-67-8

Basic information

• Product Name: 2(1H)-Quinolinone, 7-chloro-3-(3,5-dimethylphenyl)-4-hydroxy-
• CAS NO: 142326-67-8
• Molecular Formula: C17H14ClNO2
• Molecular Weight: 299.757
• Mol File: 142326-67-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2(1H)-Quinolinone, 7-chloro-3-(3,5-dimethylphenyl)-4-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinolinone, 7-chloro-3-(3,5-dimethylphenyl)-4-hydroxy-(142326-67-8)
• EPA Substance Registry System: 2(1H)-Quinolinone, 7-chloro-3-(3,5-dimethylphenyl)-4-hydroxy-(142326-67-8)

Safety Data

• Hazardous Substances Data: 142326-67-8(Hazardous Substances Data)

Upstream product

• 119423-95-9 3,5-dimethylphenylacetyl chloride 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 
• 199942-82-0 4-chloro-2-[2-(3,5-dimethylphenyl)-acetylamino]-benzoic acid methyl ester 

Downstream Products

• 199941-88-3 4-[7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-1,2-dihydro-quinolin-4-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Antagonists of gonadotropin releasing hormone

PCT No. PCT/US97/08479 Sec. 371 Date Nov. 12, 1998 Sec. 102(e) Date Nov. 12, 1998 PCT Filed May 16, 1997 PCT Pub. No. WO97/44321 PCT Pub. Date Nov. 27, 1997There are disclosed compounds of formula (I) and pharmaceutical acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related conditions.

Hydroxyquinolone derivatives compounds which have pharmaceutical utility

This present invention relates to a class of 4-hydroxy-2-(1H)-quinolones which are substituted in the 3-position by an optionally substituted aryl substituent. These compounds are selective non-competitive antagonists of N-methyl-D-aspartate (NMDA) receptors.