199941-88-3

Basic information

• Product Name: 4-[7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-1,2-dihydro-quinolin-4-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 199941-88-3
• Molecular Weight: 497.034
• Mol File: 199941-88-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-1,2-dihydro-quinolin-4-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-1,2-dihydro-quinolin-4-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester(199941-88-3)
• EPA Substance Registry System: 4-[7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-1,2-dihydro-quinolin-4-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester(199941-88-3)

Safety Data

• Hazardous Substances Data: 199941-88-3(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 199942-82-0 4-chloro-2-[2-(3,5-dimethylphenyl)-acetylamino]-benzoic acid methyl ester 
• 123855-51-6 tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 119423-95-9 3,5-dimethylphenylacetyl chloride 
• 498-94-2 isonipecotic acid 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 
• 158407-04-6 tert-butyl 4-(bromomethyl)piperidine-1-carboxylate 
• 142326-67-8 7-chloro-3-(3,5-dimethylphenyl)-4-hydroxy-1H-quinolin-2-one 

Relevant articles and documents

Identification and initial structure-activity relationships of a novel non-peptide quinolone GnRH receptor antagonist

Screening of the Merck sample collection for non-peptide compounds with binding affinity for the rat GnRH receptor led to the identification of the substituted quinolone (1) as a lead compound in the search for a non-peptide GnRH receptor antagonist. Substantial improvements in potency (~300 fold) were achieved by addition of an alkyl amine at the 4-position, a 3,5-dimethylphenyl group at the 3-position and 6-nitro-7-chlorosubstitution of the 1H-quinolone core.