142373-59-9

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-[4-[4-[2-[(butylsulfonyl)amino]-2-carboxyethyl]phenoxy]butyl]-, 1-(1,1-dimethylethyl) ester, (S)-
• CAS NO: 142373-59-9
• Molecular Formula: C27H44N2O7S
• Molecular Weight: 540.722
• Mol File: 142373-59-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-[4-[4-[2-[(butylsulfonyl)amino]-2-carboxyethyl]phenoxy]butyl]-, 1-(1,1-dimethylethyl) ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-[4-[4-[2-[(butylsulfonyl)amino]-2-carboxyethyl]phenoxy]butyl]-, 1-(1,1-dimethylethyl) ester, (S)-(142373-59-9)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-[4-[4-[2-[(butylsulfonyl)amino]-2-carboxyethyl]phenoxy]butyl]-, 1-(1,1-dimethylethyl) ester, (S)-(142373-59-9)

Safety Data

• Hazardous Substances Data: 142373-59-9(Hazardous Substances Data)

Upstream product

• 51052-78-9 4-piperidinylacetic acid 
• 142355-82-6 methyl 4-piperidin-4-yl>butanoate 
• 142355-80-4 methyl 4-piperidin-4-yl>but-2-enoate 
• 142247-38-9 4-[1-(tert-butoxycarbonyl)piperidin-4-yl]butanoic acid 
• 157688-46-5 2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid 
• 142374-19-4 tert-butyl 4-(formylmethyl)piperidine-1-carboxylate 
• 89151-44-0 4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester 
• 28356-58-3 pyridine-4-acetic acid 
• 403857-14-7 tert-butyl 4-(but-3-en-1-yl)piperidine-1-carboxylate 
• 165528-85-8 1,1-dimethylethyl 4-(3-oxopropyl)-1-piperidinecarboxylate 
• 142355-84-8 4-{4-[4-((S)-2-Benzyloxycarbonylamino-2-carboxy-ethyl)-phenoxy]-butyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 142355-81-5 tert-butyl 4-(4-bromobutyl)piperidine-1-carboxylate 
• 142355-83-7 4-(1-tert-butoxycarbonylpiperidin-4-yl)-butan-1-ol 
• 156185-63-6 N-Boc-piperidin-4-yl-propanol 

Downstream Products

• 403857-10-3 3-(2-{(S)-2-(Butane-1-sulfonylamino)-3-[4-(4-piperidin-4-yl-butoxy)-phenyl]-propionyloxy}-4,6-dimethoxy-phenyl)-3-methyl-butyric acid 
• 403857-09-0 4-[4-(4-{2-(butane-1-sulfonylamino)-2-[2-(2-carboxy-1,1-dimethyl-ethyl)-3,5-dimethoxy-phenoxycarbonyl]-ethyl}-phenoxy)-butyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 403857-08-9 1-N-Boc-tirofiban-2-[3-[(1-t-butyl-1,1-dimethylsilyl)oxyl]-1,1-dimethylpropyl]-4,6-dimethoxyphenol 
• 144494-65-5 tirofiban hydrochloride 

Relevant articles and documents

Synthesis of cyclic prodrugs of Aggrastat and its analogue with a modified phenylpropionic acid linker

(formula presented) 1a, n=2; 1b, n=1 The objective of this work was to synthesize cyclic prodrugs 1a and 1b from Aggrastat 2a and its analogue 2b, respectively, to improve their membrane permeation. Cyclic prodrugs 1a and 1b were formed using an ester bond between the -COOH group of Aggrastat or its analogue and the phenylpropionic acid linker 3 and an amide bond between the piperidinylamine and the -COOH group of the linker 3, respectively, as outlined in Scheme 4.