1426138-82-0

Basic information

• Product Name: C₃₁H₂₃FN₄O₄S
• CAS NO: 1426138-82-0
• Molecular Weight: 566.612
• Mol File: 1426138-82-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₁H₂₃FN₄O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₁H₂₃FN₄O₄S(1426138-82-0)
• EPA Substance Registry System: C₃₁H₂₃FN₄O₄S(1426138-82-0)

Safety Data

• Hazardous Substances Data: 1426138-82-0(Hazardous Substances Data)

Upstream product

• 61272-76-2 4-fluoro-2-iodoaniline 
• 371-40-4 4-fluoroaniline 
• 4290-87-3 1-prop-2-ynyl-1H-indole-2,3-dione 
• 28144-70-9 anthranilic acid amide 

Relevant articles and documents

Spiro heterocycles as potential inhibitors of SIRT1: Pd/C-mediated synthesis of novel N-indolylmethyl spiroindoline-3,2′-quinazolines

Novel N-indolylmethyl substituted spiroindoline-3,2′-quinazolines were designed as potential inhibitiors of SIRT1. These compounds were synthesized in good yields by using Pd/C-Cu mediated coupling-cyclization strategy as a key step involving the reaction of 1-(prop-2-ynyl)-1′H- spiro[indoline-3,2′-quinazoline]-2,4′(3′H)-dione with 2-iodoanilides. Some of the compounds synthesized have shown encouraging inhibition of Sir 2 protein (a yeast homologue of mammalian SIRT1) in vitro and three of them showed dose dependent inhibition of Sir 2. The docking results suggested that the benzene ring of 1,2,3,4-tetrahydroquinazolin ring system of these molecules occupied the deep hydrophobic pocket of the protein and one of the NH along with the sulfonyl group participated in strong H-bonding interaction with the amino acid residues.