1426677-90-8

Basic information

• Product Name: N-(4-fluoro-2-(hydroxymethyl)phenyl)-4-methylbenzenesulfonamide
• Synonyms: N-(4-fluoro-2-(hydroxymethyl)phenyl)-4-methylbenzenesulfonamide
• CAS NO: 1426677-90-8
• Molecular Weight: 295.334
• Mol File: 1426677-90-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: N-(4-fluoro-2-(hydroxymethyl)phenyl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-fluoro-2-(hydroxymethyl)phenyl)-4-methylbenzenesulfonamide(1426677-90-8)
• EPA Substance Registry System: N-(4-fluoro-2-(hydroxymethyl)phenyl)-4-methylbenzenesulfonamide(1426677-90-8)

Safety Data

• Hazardous Substances Data: 1426677-90-8(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 748805-85-8 (2-amino-5-fluorophenyl)methanol 
• 446-08-2 2-amino-5-fluorobenzoic acid 

Downstream Products

• 1426677-83-9 N-(4-fluoro-2-formylphenyl)-4-methyl-N-(2-oxo-2-phenylethyl)benzenesulfonamide 
• 1426678-15-0 (R)-6-fluoro-3-hydroxy-3-phenyl-1-tosyl-2,3-dihydroquinolin-4(1H)-one 
• 1426678-00-3 C₂₂H₂₀FNO₄S 
• 1613505-71-7 C₁₇H₁₆FNO₃S 
• 1613505-64-8 C₂₆H₂₂FNO₅S 
• 1613505-49-9 C₂₄H₁₈FNO₃S 

Relevant articles and documents

A [4+3] Cycloaddition Reaction of Aza-ortho-quinone Methides with C,N-Cyclic Azomethine Imines for Synthesis of 1,2,4-Triazepines

The base-induced formal [4+3] cycloaddition reaction of C,N-cyclic azomethine imines with aza-ortho-quinone methides, generated in situ, is reported. This protocol provided an efficient method for the synthesis of biologically important 1,2,4-triazepine derivatives, with a wide substrate scope and excellent functional-group tolerance, and it gives moderate to excellent yields under mild conditions. Several of the derivatives exhibited in vitro antitumor activities against the A2780 cell line in a screening of the cancer cell lines HCT-116, H2228, and A2780 by an MTT assay.

Benzoazepine-Fused Isoindolines via Intramolecular (3 + 2)-Cycloadditions of Azomethine Ylides with Dinitroarenes

Aminobenzaldehydes bearing a pendant 3,5-dinitrophenyl group react thermally with N-substituted α-amino acids to form unprecedented benzoazepine-fused isoindolines. The reaction proceeds via a dearomatization/rearomatization sequence involving an intramolecular (3 + 2)-cycloaddition between the in situ formed azomethine ylide and the dinitroarene. Various glycine derivatives are tolerated as well as branched substrates based on cyclic, α-mono-, and α,α-disubstituted amino acids, giving single diastereomers in many cases. The method is scalable and gives products with a nitro group ready for further manipulation.

Catalytic Asymmetric [4 + 3] Annulation of C, N-Cyclic Azomethine Imines with Copper Allenylidenes

The first asymmetric decarboxylative [4 + 3] annulation of propargylic carbamates with C,N-cyclic azomethine imines has been developed successfully by a copper-N-heterocyclic carbine system. This strategy led to a series of optically active isoquinoline-f