142763-11-9

Basic information

• Product Name: 2-Oxazolidinone, 4-[(3,4-dimethoxyphenyl)methyl]-, (S)-
• CAS NO: 142763-11-9
• Molecular Formula: C12H15NO4
• Molecular Weight: 237.255
• Mol File: 142763-11-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Oxazolidinone, 4-[(3,4-dimethoxyphenyl)methyl]-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxazolidinone, 4-[(3,4-dimethoxyphenyl)methyl]-, (S)-(142763-11-9)
• EPA Substance Registry System: 2-Oxazolidinone, 4-[(3,4-dimethoxyphenyl)methyl]-, (S)-(142763-11-9)

Safety Data

• Hazardous Substances Data: 142763-11-9(Hazardous Substances Data)

Upstream product

• 105779-71-3 (S)-(-)-[2-(3,4-dimethoxyphenyl)-1-hydroxymethylethyl]carbamic acid tert-butyl ester 
• 30033-24-0 (2S)-3-(3,4-dihydroxyphenyl)-2-[(tert-butoxy)carbonylamino]propanoic acid 
• 59-92-7 levodopa 
• 138908-56-2 (S)-(+)-2-tert-butoxycarbonylamino-3-(3,4-dimethoxyphenyl)propionic acid methyl ester 

Downstream Products

• 4640-41-9 2,3-dichloro-5,6-dicyanohydroquinone 
• 1373614-10-8 (4S)-4-(3,4-dimethoxybenzyl)-3-(propa-1,2-dienyl)oxazolidin-2-one 
• 1373614-09-5 C₁₅H₁₇NO₄ 

Relevant articles and documents

Nitrogen (oxygen) heterocyclic pentane - 2 - one (thione) compound, pharmaceutical composition, preparation method and use thereof

The invention belongs to the field of pharmacology, and relates to aza (oxa)-cyclopentane-2- ketone (thione) compounds shown in the formula I, medicine compositions thereof, a preparation method, applications in preparation of medicines treating diabetes and glucolipid metabolism, and especially applications in preparation of medicines treating II-type diabetes.

Oxidative nucleophilic substitution (SNOX) of the benzylic position as a tunable synthesis of tetrahydroisoquinoline natural alkaloid analogues

Synthetic investigations of 1,3-dichloro-5,6-dicyanobenzoquinone-mediated benzylic oxidation is reported for the synthesis of natural alkaloid analogues. Extensive explorations of the oxidative nucleophilic substitution of the benzylic position of β-phenylethylamine derivatives and the synthesis of functionalized tetrahydroisoquinolines of ecteinascidin 743 precursors have been carried out. Starting from L-DOPA, a tunable oxazolidinone group was installed under oxidative benzylic conditions. This derivative 13 was submitted to benzylic oxidation reactions using a wide range of carboxylic acids and subsequent chemical transformations of these compounds were attempted. Moreover, an efficient synthesis of an aromatic ketone derivative 20 was achieved and gave rise to tetrahydroisoquinoline 24 through a direct Pictet-Spengler cyclisation reaction. Subsequently, 24 was transformed into functionahzed α-amino alcohols 31a and 31b, precursors of ecteinascidin 743 analogues. In addition, in order to assess the viability of our synthetic strategy, the reaction of 24 with methyl thioglycolate was performed and the stereoselectivity confirmed by X-ray analysis of 33a. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.