1428640-45-2

Basic information

• Product Name: C₁₅H₁₆Cl₂N₄
• CAS NO: 1428640-45-2
• Molecular Weight: 323.225
• Mol File: 1428640-45-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₆Cl₂N₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₆Cl₂N₄(1428640-45-2)
• EPA Substance Registry System: C₁₅H₁₆Cl₂N₄(1428640-45-2)

Safety Data

• Hazardous Substances Data: 1428640-45-2(Hazardous Substances Data)

Upstream product

• 7400-27-3 tertbutylhydrazine hydrochloride 
• 82302-32-7 2-(2,3-dichlorophenyl)acetyl chloride 
• 10236-60-9 (2,3-dichlorophenyl)acetic acid 
• 32064-67-8 tert-butylhydrazine 

Downstream Products

• 956026-43-0 1-tert-butyl-3-(2,3-dichlorobenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 

Relevant articles and documents

Discovery of a potent protein kinase D inhibitor: insights in the binding mode of pyrazolo[3,4-d]pyrimidine analogues

In this study, we set out to rationally optimize PKD inhibitors based on the pyrazolo[3,4-d]pyrimidine scaffold. The lead compound for this study was 1-NM-PP1, which was previously found by us and others to inhibit PKD. In our screening we identified one compound (3-IN-PP1) displaying a 10-fold increase in potency over 1-NM-PP1, opening new possibilities for specific protein kinase inhibitors for kinases that show sensitivity towards pyrazolo[3,4-d]pyrimidine derived compounds. Interestingly the observed SAR was not in complete agreement with the commonly observed binding mode where the pyrazolo[3,4-d]pyrimidine compounds are bound in a similar fashion as PKD's natural ligand ATP. Therefore we suggest an alternate binding mode where the compounds are flipped 180 degrees. This possible alternate binding mode for pyrazolo[3,4-d]pyrimidine based compounds could pave the way for a new class of specific protein kinase inhibitors for kinases sensitive towards pyrazolo[3,4-d]pyrmidines.