143014-18-0

Basic information

• Product Name: Benzene, 4-iodo-1-isothiocyanato-2-methyl-
• CAS NO: 143014-18-0
• Molecular Formula: C8H6INS
• Molecular Weight: 275.113
• Mol File: 143014-18-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzene, 4-iodo-1-isothiocyanato-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 4-iodo-1-isothiocyanato-2-methyl-(143014-18-0)
• EPA Substance Registry System: Benzene, 4-iodo-1-isothiocyanato-2-methyl-(143014-18-0)

Safety Data

• Hazardous Substances Data: 143014-18-0(Hazardous Substances Data)

Upstream product

• 463-71-8 thiophosgene 
• 13194-68-8 4-iodo-2-methylaniline 

Downstream Products

• 905917-25-1 3-hydroxy-5-(4-iodo-2-methyl-phenylamino)-isothiazole-4-carbonitrile 
• 905917-16-0 2-cyano-2-(4-iodo-2-methyl-phenylthiocarbamoyl)-acetamide 

Relevant articles and documents

A metal-free synthesis of 2-aminobenzothiazoles through aminyl radical addition to aryl isothiocyanates

A convenient synthesis of 2-aminobenzothiazoles, starting from aryl isothiocyanates and formamides under metal-free conditions, is described. Various secondary and tertiary amine- and even α-amino acid-derived formamides can be used as amino sources in this process. Mechanistic studies suggest that the reaction is initiated by decarbonylative aminyl radical formation in the presence of n-Bu4NI and TBHP, followed by aminyl radical addition to isothiocyanates and cyclization via sulfur centred radical intermediates.

THIENO-PYRIDINE DERIVATIVES AS MEK INHIBITORS

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