1430730-41-8

Basic information

• Product Name: 4-benzyl-5-(4-methoxyphenyl)-3-(2',3',4',6'-tetra-O-benzoyl-β-D-glucopyranosyl)-1,2,4-triazole
• Synonyms: 4-benzyl-5-(4-methoxyphenyl)-3-(2',3',4',6'-tetra-O-benzoyl-β-D-glucopyranosyl)-1,2,4-triazole
• CAS NO: 1430730-41-8
• Molecular Weight: 843.89
• Mol File: 1430730-41-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-benzyl-5-(4-methoxyphenyl)-3-(2',3',4',6'-tetra-O-benzoyl-β-D-glucopyranosyl)-1,2,4-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzyl-5-(4-methoxyphenyl)-3-(2',3',4',6'-tetra-O-benzoyl-β-D-glucopyranosyl)-1,2,4-triazole(1430730-41-8)
• EPA Substance Registry System: 4-benzyl-5-(4-methoxyphenyl)-3-(2',3',4',6'-tetra-O-benzoyl-β-D-glucopyranosyl)-1,2,4-triazole(1430730-41-8)

Safety Data

• Hazardous Substances Data: 1430730-41-8(Hazardous Substances Data)

Upstream product

• 7465-87-4 N-benzyl-4-methoxybenzamide 
• 706784-62-5 5-(2',3',4',6'-tetra-O-benzoyl-β-D-glucopyranosyl)tetrazole 
• 100-46-9 benzylamine 
• 100-07-2 4-methoxy-benzoyl chloride 

Downstream Products

• 1430730-57-6 4-benzyl-5-(β-D-glucopyranosyl)-3-(4-methoxyphenyl)-1,2,4-triazole 

Relevant articles and documents

New synthesis of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazoles, nanomolar inhibitors of glycogen phosphorylase

O-Perbenzoylated 5-(β-D-glucopyranosyl)tetrazole was reacted with N-benzyl carboximidoyl chlorides to give the corresponding 4-benzyl-3-(β-D- glucopyranosyl)-5-substituted-1,2,4-triazoles. Removal of the O-benzoyl and N-benzyl protecting groups by base catalysed transesterification and catalytic hydrogenation, respectively, furnished a series of 3-(β-D-glucopyranosyl)- 5-substituted-1,2,4-triazoles with aliphatic, mono- and bicyclic aromatic, and heterocyclic substituents in the 5-position. Enzyme kinetic studies revealed these compounds to inhibit rabbit muscle glycogen phosphorylase b: best inhibitors were the 5-(4-aminophenyl)- (Ki 0.67 μM) and the 5-(2-naphthyl)-substituted (Ki 0.41 μM) derivatives. This study uncovered the C-glucopyranosyl-1,2,4-triazoles as a novel skeleton for nanomolar inhibition of glycogen phosphorylase.