7465-87-4

Basic information

• Product Name: BenzaMide, 4-Methoxy-N-(phenylMethyl)-
• Synonyms: BenzaMide, 4-Methoxy-N-(phenylMethyl)-
• CAS NO: 7465-87-4
• Molecular Formula: C₁₅H₁₅NO₂
• Molecular Weight: 241.2851
• Mol File: 7465-87-4.mol
• Article Data: 189

Chemical Properties

• Boiling Point: 441.2°Cat760mmHg
• Flash Point: 220.6°C
• Appearance: /Solid
• Density: 1.124g/cm³
• Vapor Pressure: 5.56E-08mmHg at 25°C
• Refractive Index: 1.576
• Water Solubility: Soluble in water.
• CAS DataBase Reference: BenzaMide, 4-Methoxy-N-(phenylMethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzaMide, 4-Methoxy-N-(phenylMethyl)-(7465-87-4)
• EPA Substance Registry System: BenzaMide, 4-Methoxy-N-(phenylMethyl)-(7465-87-4)

Safety Data

• Hazardous Substances Data: 7465-87-4(Hazardous Substances Data)

Usage

General Description

Benzamide, 4-Methoxy-N-(phenylmethyl)- is a chemical compound with the molecular formula C15H15NO2. It is a member of the benzamide family, which are organic compounds containing the benzamide structure, consisting of a benzene ring with an amide group attached. This specific compound contains a 4-methoxy substituent and a phenylmethyl substituent. It is commonly used in organic synthesis and pharmaceutical research as a building block for creating other complex molecules. The compound has potential therapeutic applications as well, particularly in the development of new drugs for various medical conditions.

InChI:InChI=1/C15H15NO2/c1-18-14-9-7-13(8-10-14)15(17)16-11-12-5-3-2-4-6-12/h2-10H,11H2,1H3,(H,16,17)

Upstream product

• 858790-28-0 3,7-bis-(4-methoxy-benzoyl)-2,8-bis-(4-methoxy-phenyl)-pyrano[3,2-g]chromene-4,6-dione 
• 100-46-9 benzylamine 
• 100-07-2 4-methoxy-benzoyl chloride 
• 1020-67-3 ethyl 3-(benzylamino)crotonate 
• 100-09-4 4-methoxybenzoic acid 
• 121-98-2 methyl 4-methoxybenzoate 
• 94-30-4 ethyl 4-methoxybenzoate 
• 3532-17-0 4-methoxybenzoyl azide 
• 52898-56-3 N_.O-Dianisoyl-N-methyl-hydroxylamin 
• 7464-46-2 p-nitrophenyl p-methoxybenzoate 
• 3424-93-9 4-methoxyphenylacetamide 
• 100-52-7 benzaldehyde 
• 110-86-1 pyridine 
• 98-09-9 benzenesulfonyl chloride 

Downstream Products

• 68055-31-2 N-benzyl-4-methoxybenzenecarbothioamide 
• 3424-93-9 4-methoxyphenylacetamide 
• 619-57-8 p-hydroxybenzamide 
• 876893-18-4 N-[(1H-1,2,3-benzotriazol-1-yl)(4-methoxyphenyl)methylidene]-N-benzylamine 
• 100-52-7 benzaldehyde 
• 874-90-8 4-methoxybenzonitrile 
• 1269762-46-0 C₇₅H₁₃NO₂ 
• 14429-02-8 benzyl-(4-methoxybenzyl)amine 
• 111865-51-1 N-[1-(4-methoxyphenyl)-3-butenyl]benzylamine 
• 105-13-5 4-Methoxybenzyl alcohol 
• 100-46-9 benzylamine 
• 171503-10-9 diethyl ((benzylamino)(4-methoxyphenyl)methyl)phosphonate 
• 1430730-41-8 4-benzyl-5-(4-methoxyphenyl)-3-(2',3',4',6'-tetra-O-benzoyl-β-D-glucopyranosyl)-1,2,4-triazole 

Relevant articles and documents

TBAI-catalyzed C–N bond formation through oxidative coupling of benzyl bromides with amines: a new avenue to the synthesis of amides

A new green approach for the synthesis of amide through TBAI-catalyzed oxidative coupling of benzyl bromides with amine was developed in the presence of tert-butyl hydroperoxide (TBHP) as an oxidant. Various electron-donating and withdrawing groups containing benzyl bromides and various amines, were subjected to the reaction and transformed to the corresponding amide in good to excellent yields.

Cobalt catalysed aminocarbonylation of thiols in batch and flow for the preparation of amides

The synthesis of amides from thiols through a cobalt-catalyzed aminocarbonylation is shown. After optimizing all the reaction parameters, the methodology makes possible the obtention of amides with variable yields, while competing reactions such as the formation of disulfides and ureas can be limited. The process works well with aromatic thiols with electron donating groups (EDG) whereas other thiols give reaction with lower yields. The previous process has been transferred and optimized into flow equipment, thus allowing using less CO in a safer way, and permitting the scaling up of the synthesis. Two drugs, moclobemide and itopride were prepared with this methodology, albeit only in the second case with good results. A mechanistic pathway is proposed.

Direct synthesis of amides and imines by dehydrogenative homo or cross-coupling of amines and alcohols catalyzed by Cu-MOF

Oxidative dehydrogenative homo-coupling of amines to imines and cross-coupling of amines with alcohols to amides was achieved with high to moderate yields at room temperature in THF using Cu-MOF as an efficient and recyclable heterogeneous catalyst under mild conditions. Different primary benzyl amines and alcohols could be utilized for the synthesis of a wide variety of amides and imines. The Cu-MOF catalyst could be recycled and reused four times without loss of catalytic activity.