1431081-02-5

Basic information

• Product Name: N-(4-methoxycarbonyl-2-methoxybenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorene
• Synonyms: N-(4-methoxycarbonyl-2-methoxybenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorene
• CAS NO: 1431081-02-5
• Molecular Weight: 367.469
• Mol File: 1431081-02-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-methoxycarbonyl-2-methoxybenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorene(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methoxycarbonyl-2-methoxybenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorene(1431081-02-5)
• EPA Substance Registry System: N-(4-methoxycarbonyl-2-methoxybenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorene(1431081-02-5)

Safety Data

• Hazardous Substances Data: 1431081-02-5(Hazardous Substances Data)

Upstream product

• 1072-72-6 Tetrahydrothiopyran-4-one 
• 70264-94-7 methyl 4-(bromomethyl)-3-methoxybenzoate 
• 7076-17-7 1,3,4,5-tetrahydrothiopyrano[4,3-b]indole 

Downstream Products

• 1431080-94-2 N-(4-hydroxycarbamoyl-2-methoxybenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorene 

Relevant articles and documents

Potent and selective HDAC6 inhibitory activity of N-(4- hydroxycarbamoylbenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorenes as novel sulfur analogues of Tubastatin A

Eight N-(4-hydroxycarbamoylbenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorenes were efficiently prepared as sulfur analogues of Tubastatin A and thus evaluated as new HDAC6 inhibitors. All compounds exhibited potency against HDAC6, and four of them were active in the nanomolar range (IC50 = 1.9-22 nM). Further analysis revealed that the sulfone derivatives (designated as Tubathians) are superior to their non-oxidized sulfide analogues, and the two most active sulfones showed good to excellent HDAC6 selectivity compared to all other HDAC isoform classes.