7076-17-7Relevant articles and documents
Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition
Depetter, Yves,Geurs, Silke,Vanden Bussche, Flore,De Vreese, Rob,Franceus, Jorick,Desmet, Tom,De Wever, Olivier,D'Hooghe, Matthias
, p. 1011 - 1016 (2018)
Recent studies point towards the possible disadvantages of using hydroxamic acid-based zinc-binding groups in HDAC inhibitors due to e.g. mutagenicity issues. In this work, we elaborated on our previously developed Tubathian series, a class of highly sele
Asymmetric N-Hydroxyalkylation of Indoles with Ethyl Glyoxalates Catalyzed by a Chiral Phosphoric Acid: Highly Enantioselective Synthesis of Chiral N,O-Aminal Indole Derivatives
Wang, Le,Zhou, Jia,Ding, Tong-Mei,Yan, Zhi-Qiang,Hou, Si-Hua,Zhu, Guo-Dong,Zhang, Shu-Yu
supporting information, p. 2795 - 2799 (2019/04/30)
A method of SPINOL-derived chiral phosphoric acid catalyzed asymmetric intermolecular N-hydroxyalkylation of multisubstituted indoles with ethyl glyoxalates is described in this report. This protocol provides an alternative, convenient, and direct strategy for efficient access to structurally unique α-chiral indole N,O-acyclic aminals with a broad substrate scope and good to excellent enantioselectivities. The synthetic utility of this methodology is illustrated by a gram-scale experiment and the subsequent efficient synthesis of more complex chiral N,O-aminal indole derivatives.
Thiapyran[4,3-b] indole compound and preparing method and application thereof
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Paragraph 0063; 0065-0067; 0068; 0069, (2018/10/19)
The invention discloses a thiapyran[4,3-b] indole compound and a preparing method and application thereof. The structure of the compound is shown in the formula 1, wherein the formula 1 is shown in the description, and R1-R5 are not all hydrogen. The compound has excellent activities of inhibiting mycelial growth, protecting detached leaves, protecting living bodies and treating the living bodiesfor rhizoctonia solani, the effects of the compound are even superior to those of positive control drugs, and the compound has an important application value in preventing and/or treating rice sheathblight.