1431163-23-3

Basic information

• Product Name: C₁₉H₃₁ClN₂Sn
• CAS NO: 1431163-23-3
• Molecular Weight: 441.632
• Mol File: 1431163-23-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₃₁ClN₂Sn(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₃₁ClN₂Sn(1431163-23-3)
• EPA Substance Registry System: C₁₉H₃₁ClN₂Sn(1431163-23-3)

Safety Data

• Hazardous Substances Data: 1431163-23-3(Hazardous Substances Data)

Upstream product

• 1461-22-9 tributyltin chloride 
• 908267-60-7 7-chloro-3-iodoimidazo[1,2-a]pyridine 
• 4532-25-6 7-chloroimidazo-[1,2-a]pyridine 

Relevant articles and documents

Strategic use of conformational bias and structure based design to identify potent JAK3 inhibitors with improved selectivity against the JAK family and the kinome

Using a structure based design approach we have identified a series of indazole substituted pyrrolopyrazines, which are potent inhibitors of JAK3. Intramolecular electronic repulsion was used as a strategy to induce a strong conformational bias within the ligand. Compounds bearing this conformation participated in a favorable hydrophobic interaction with a cysteine residue in the JAK3 binding pocket, which imparted high selectivity versus the kinome and improved selectivity within the JAK family.