908267-60-7

Basic information

• Product Name: 7-chloro-3-iodoH-iMidazo[1,2-a]pyridine
• Synonyms: 7-chloro-3-iodoH-iMidazo[1,2-a]pyridine;IMidazo[1,2-a]pyridine, 7-chloro-3-iodo-;7-Chloro-3-iodo-iMidazo[1,2-a]pyridine;7-Chloro-3-iodo-1,5-dihydroimidazo[1,2-a]pyridine
• CAS NO: 908267-60-7
• Molecular Formula: C₇H₄ClIN₂
• Molecular Weight: 280.49
• Mol File: 908267-60-7.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7-chloro-3-iodoH-iMidazo[1,2-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chloro-3-iodoH-iMidazo[1,2-a]pyridine(908267-60-7)
• EPA Substance Registry System: 7-chloro-3-iodoH-iMidazo[1,2-a]pyridine(908267-60-7)

Safety Data

• Hazardous Substances Data: 908267-60-7(Hazardous Substances Data)

Usage

Description

7-chloro-3-iodoH-imidazo[1,2-a]pyridine is a heterocyclic chemical compound with the molecular formula C7H4ClIN2. It features both chlorine and iodine atoms within its structure, which contributes to its unique reactivity and properties. 7-chloro-3-iodoH-imidazo[1,2-a]pyridine is often utilized in organic synthesis and pharmaceutical research due to its potential as a building block for the creation of various biologically active molecules.

Uses

Used in Organic Synthesis:
7-chloro-3-iodoH-imidazo[1,2-a]pyridine is used as a key intermediate in organic synthesis for the development of new chemical entities. Its strong nucleophilic and electrophilic properties allow for versatile reactions, facilitating the construction of complex molecular structures.
Used in Pharmaceutical Research:
In pharmaceutical research, 7-chloro-3-iodoH-imidazo[1,2-a]pyridine serves as a valuable reagent for the synthesis of potential drug candidates. Its unique structure and reactivity make it instrumental in the design and development of new drugs and other bioactive compounds, contributing to advancements in medicinal chemistry.
Used in the Development of Bioactive Compounds:
7-chloro-3-iodoH-imidazo[1,2-a]pyridine is employed as a precursor in the creation of bioactive compounds across various fields, including but not limited to, agrochemicals, materials science, and environmental chemistry. Its role in these applications is to provide a foundation for the synthesis of molecules with specific biological activities or properties.

Upstream product

• 4532-25-6 7-chloroimidazo-[1,2-a]pyridine 
• 130721-78-7 tert-butyl (4-chloropyridin-2-yl) carbamate 
• 19798-80-2 2-Amino-4-chloropyridine 
• 516-12-1 N-iodo-succinimide 

Downstream Products

• 1036761-84-8 3-(7-chloroimidazo[1,2-a]pyridin-3-yl)aniline 
• 1036986-17-0 1-(3-(7-chloroimidazo[1,2-a]pyridin-3-yl)phenyl)-3-(2,2,2-trifluoroethyl)urea 
• 1421589-68-5 7-chloro-3-(4-ethoxyphenyl)imidazo[1,2-a]pyridine 
• 1345687-68-4 ethyl [4-(7-chloroimidazo[1,2-a]pyridin-3-yl)phenoxy]acetate 
• 1431163-23-3 C₁₉H₃₁ClN₂Sn 
• 1421589-41-4 3-(4-ethoxyphenyl)-N-[(4-ethylphenyl)-methyl]imidazo[1,2-a]pyridin-7-amine 
• 1036991-14-6 1-{3-[7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-phenyl}-3-(2,2,2-trifluoro-ethyl)-urea 
• 1201652-99-4 1-[3-(7-pyridin-2-ylimidazo[1,2-a]pyridin-3-yl)phenyl]-3-(2,2,2-trifluoroethyl)urea 
• 1201654-55-8 1-(3-{7-[2-(3-methyl-3H-imidazol-4-yl)-ethyl]-imidazo[1,2-a]pyridin-3-yl}-phenyl)-3-(2,2,2-trifluoro-ethyl)-urea 
• 1201653-11-3 1-[3-(7-pyridin-3-ylethynylimidazo[1,2-a]pyridin-3-yl)phenyl]-3-(2,2,2-trifluoroethyl)urea 
• 1201653-15-7 1-{3-[7-(3-methyl-3H-imidazol-4-ylethynyl)imidazo[1,2-a]pyridin-3-yl]phenyl}-3-(2,2,2-trifluoroethyl)urea 
• 1201653-10-2 1-(3-{7-[1-(2-hydroxy-1,1-dimethylethyl)-1H-pyrazol-4-yl]-imidazo[1,2-a]pyridin-3-yl}phenyl)-3-(2,2,2-trifluoroethyl)urea 
• 1201653-03-3 2-methyl-2-[4-(3-{3-[3-(2,2,2-trifluoroethyl)ureido]phenyl}imidazo[1,2-a]pyridin-7-yl)pyrazol-1-yl]propionic acid 
• 1201653-24-8 1-(2,2,2-trifluoroethyl)-3-{3-[7-(5-trifluoromethyl[1,3,4]thiadiazol-2-yl)-imidazo[1,2-a]pyridin-3-yl]phenyl}urea 

Relevant articles and documents

From Synthetic Simplified Marine Metabolite Analogues to New Selective Allosteric Inhibitor of Aurora B Kinase

Significant inhibition of Aurora B was achieved by the synthesis of simplified fragments of benzosceptrins and oroidin belonging to the marine pyrrole-2-aminoimidazoles metabolites isolated from sponges. Evaluation of kinase inhibition enabled the discovery of a synthetically accessible rigid acetylenic structural analogue EL-228 (1), whose structure could be optimized into the potent CJ2-150 (37). Here we present the synthesis of new inhibitors of Aurora B kinase, which is an important target for cancer therapy through mitosis regulation. The biologically oriented synthesis yielded several nanomolar inhibitors. The optimized compound CJ2-150 (37) showed a non-ATP competitive allosteric mode of action in a mixed-type inhibition for Aurora B kinase. Molecular docking identified a probable binding mode in the allosteric site "F"and highlighted the key interactions with the protein. We describe the improvement of the inhibitory potency and specificity of the novel scaffold as well as the characterization of the mechanism of action.

Strategic use of conformational bias and structure based design to identify potent JAK3 inhibitors with improved selectivity against the JAK family and the kinome

Using a structure based design approach we have identified a series of indazole substituted pyrrolopyrazines, which are potent inhibitors of JAK3. Intramolecular electronic repulsion was used as a strategy to induce a strong conformational bias within the ligand. Compounds bearing this conformation participated in a favorable hydrophobic interaction with a cysteine residue in the JAK3 binding pocket, which imparted high selectivity versus the kinome and improved selectivity within the JAK family.

[5,6]HETEROCYCLIC COMPOUND

Abstract: An object of the present invention is to provide a novel low molecular weight compound exhibiting an osteogenesis-promoting action. This object is achieved by a compound having the general formula (I) or a pharmacologically acceptable salt thereof. In the general formula (I), R1 and R2 represent hydrogen atoms, and the like; R3 represents a hydrogen atom, and the like; X, Y, and Z represent nitrogen atoms, and the like; A represents a phenylene group, and the like; n represents 1 or 2, and the like; and V and W represent oxygen atoms, and the like.