1431723-76-0

Basic information

• Product Name: C₂₂H₂₆N₂O₆S
• CAS NO: 1431723-76-0
• Molecular Weight: 446.524
• Mol File: 1431723-76-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₆N₂O₆S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₆N₂O₆S(1431723-76-0)
• EPA Substance Registry System: C₂₂H₂₆N₂O₆S(1431723-76-0)

Safety Data

• Hazardous Substances Data: 1431723-76-0(Hazardous Substances Data)

Upstream product

• 7467-90-5 2-hydroxy-1,2-di(3,4,5-trimethoxyphenyl)ethanone 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 

Relevant articles and documents

Design, synthesis, cytotoxic evaluation and tubulin inhibitory activity of 4-aryl-5-(3,4,5-trimethoxyphenyl)-2-alkylthio-1H-imidazole derivatives

A new series of 4-aryl-5-(3,4,5-trimethoxyphenyl)-2-alkylthio-1H-imidazoles were synthesized and their cytotoxic activities in vitro against four different cell lines (HT-29, MCF-7, NIH-3T3, AGS) were evaluated. Compound 6g bearing 3,4,5-trimethoxyphenyl moiety on ring A and 4-methoxy substituent on ring B displayed potent cytotoxic activity against all cell lines. Flow cytometry analysis and microtubule polymerization assay confirmed that cytotoxic activities of this compound were related to inhibitory effect against microtubules polymerization. Molecular modeling studies revealed that compound 6g could strongly bind to the colchicine binding site of α,β-tubulin through hydrogen bond interactions with Thrα179 and Cysβ241.