7467-90-5

Basic information

• Product Name: 3,3'',4,4'',5,5''-Hexamethoxybenzoin
• Synonyms: 3,3'',4,4'',5,5''-Hexamethoxybenzoin
• CAS NO: 7467-90-5
• Molecular Formula: C₂₀H₂₄O₈
• Molecular Weight: 392.39976
• Mol File: 7467-90-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 535.6°Cat760mmHg
• Flash Point: 184.2°C
• Appearance: /
• Density: 1.211g/cm³
• Vapor Pressure: 2.66E-12mmHg at 25°C
• Refractive Index: 1.544
• CAS DataBase Reference: 3,3'',4,4'',5,5''-Hexamethoxybenzoin(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3'',4,4'',5,5''-Hexamethoxybenzoin(7467-90-5)
• EPA Substance Registry System: 3,3'',4,4'',5,5''-Hexamethoxybenzoin(7467-90-5)

Safety Data

• Hazardous Substances Data: 7467-90-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C20H24O8/c1-23-13-7-11(8-14(24-2)19(13)27-5)17(21)18(22)12-9-15(25-3)20(28-6)16(10-12)26-4/h7-10,17,21H,1-6H3

Upstream product

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 

Downstream Products

• 102449-88-7 4,5-bis-(3,4,5-trimethoxy-phenyl)-3H-oxazol-2-one 
• 97059-82-0 4,5-Bis-(3,4,5-trimethoxy-phenyl)-1,3-dihydro-imidazole-2-thione 
• 97059-67-1 5,6-Bis-(3,4,5-trimethoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole 
• 1431723-76-0 C₂₂H₂₆N₂O₆S 
• 1431723-83-9 C₂₃H₂₈N₂O₆S 
• 52605-12-6 1,2-bis(3,4,5-tri-methoxyphenyl)ethane-1,2-dione 

Relevant articles and documents

Polysiloxanes-based stationary phases containing methoxy-substituted tetraphenyl-phenyl groups for gas chromotographic separations

3,4-Di(4-methoxy phenyl)-2,5-diphenyl phenyl grafted polysiloxane (MTP) and 3,4-di(3,4,5-trimethoxy phenyl)-2,5-diphenyl phenyl grafted polysiloxane (TMP) were synthesized and statically coated on fused silica capillary columns. The MTP and TMP columns have efficiencies of almost 3400 (k = 3.74, 0.25 mm i.d.) and 3600 (k = 3.96, 0.25 mm i.d.) plates per m, respectively, which are determined by naphthalene at 120 °C. Both columns exhibited moderate polarity based on the McReynolds constants. The separation of the polyethylene pyrolysis products shows that the maximum operating temperature of the two columns can reach up to 360 °C and 370 °C, respectively. In addition, the solvation parameter indicated that the dipole-induced dipole, H-bond alkaline, and dispersive interactions were the main interactions between the solutes and the stationary phases. The separation performance of the new columns was evaluated by gas chromatography separation of the Grob test mixtures. Several mixtures with π-conjugated structure were also well separated on the new columns. This work demonstrated the promising future of the new type of stationary phases in GC analysis.

Synthesis of 3,4-bis (3, 4, 5-trimethoxyphenyl) - 2,5-diphenyl-cyclopentadienone method

The invention discloses a method for synthesizing 3, 4-di(3, 4, 5-trimethoxy phenyl)-2, 5-diphenyl cyclopentadienone. The method comprises the following steps: carrying out condensation reaction on 3, 4, 5-trimethoxy benzaldehyde serving as a raw material

Design, synthesis, cytotoxic evaluation and tubulin inhibitory activity of 4-aryl-5-(3,4,5-trimethoxyphenyl)-2-alkylthio-1H-imidazole derivatives

A new series of 4-aryl-5-(3,4,5-trimethoxyphenyl)-2-alkylthio-1H-imidazoles were synthesized and their cytotoxic activities in vitro against four different cell lines (HT-29, MCF-7, NIH-3T3, AGS) were evaluated. Compound 6g bearing 3,4,5-trimethoxyphenyl moiety on ring A and 4-methoxy substituent on ring B displayed potent cytotoxic activity against all cell lines. Flow cytometry analysis and microtubule polymerization assay confirmed that cytotoxic activities of this compound were related to inhibitory effect against microtubules polymerization. Molecular modeling studies revealed that compound 6g could strongly bind to the colchicine binding site of α,β-tubulin through hydrogen bond interactions with Thrα179 and Cysβ241.