1431943-79-1

Basic information

• Product Name: 6-fluoro-3-({4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}acetyl)-2-methylbenzonitrile
• Synonyms: 6-fluoro-3-({4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}acetyl)-2-methylbenzonitrile
• CAS NO: 1431943-79-1
• Molecular Weight: 465.481
• Mol File: 1431943-79-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-fluoro-3-({4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}acetyl)-2-methylbenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-fluoro-3-({4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}acetyl)-2-methylbenzonitrile(1431943-79-1)
• EPA Substance Registry System: 6-fluoro-3-({4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}acetyl)-2-methylbenzonitrile(1431943-79-1)

Safety Data

• Hazardous Substances Data: 1431943-79-1(Hazardous Substances Data)

Upstream product

• 1255206-68-8 4-methyl-5-oxiran-2-yl-2-benzofuran-1(3H)-one 
• 1255206-69-9 5-ethenyl-4-methyl-2-benzofuran-1(3H)-one 
• 1255206-67-7 5-bromo-4-methyl-2-benzofuran-1(3H)-one 
• 83647-43-2 3-bromo-2-methylbenzyl alcohol 
• 76006-33-2 3-bromo-2-methylbenzoic acid 
• 1255206-70-2 4-methyl-5-[2R-oxiran-2-yl]-2-benzofuran-1(3H)-one 
• 1431944-43-2 6-fluoro-2-methyl-3-[{2-oxopiperazin-1-yl}acetyl]benzonitrile 

Relevant articles and documents

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir 1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.