1432488-16-8

Basic information

• Product Name: C₃₃H₃₉F₃N₆OS
• Synonyms: C₃₃H₃₉F₃N₆OS
• CAS NO: 1432488-16-8
• Molecular Weight: 624.773
• Mol File: 1432488-16-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₃H₃₉F₃N₆OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₃H₃₉F₃N₆OS(1432488-16-8)
• EPA Substance Registry System: C₃₃H₃₉F₃N₆OS(1432488-16-8)

Safety Data

• Hazardous Substances Data: 1432488-16-8(Hazardous Substances Data)

Upstream product

• 1417526-55-6 2-(hydroxymethyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazole-5-carbaldehyde 
• 312936-81-5 1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazole-5-carbaldehyde 
• 312936-79-1 (1-((4’-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-5-yl)methanol 
• 220364-22-7 1-(4-Bromobenzyl)-5-hydroxymethyl-1H-imidazole 
• 106-40-1 4-bromo-aniline 
• 312936-77-9 1-(4-Bromobenzyl)-2-Mercapto-5-Hydroxymethylimidazole 
• 2290-65-5 trimethylsilyl isothiocyanate 
• 1432488-15-7 1-((5-(((2-(diethylamino)ethyl)(methyl)amino)methyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-2-yl)methyl)-2-thioxo-2,3,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4(5H)-one 

Relevant articles and documents

Triazole derivatives: A series of Darapladib analogues as orally active Lp-PLA2 inhibitors

This Letter reports our efforts towards the optimization of our previously identified series of imidazole and triazole derivatives that lead to the discovery of a series of orally active Lp-PLA2 inhibitors in C57 mice. These inhibitors are characterized by the presence of a diamine side chain in the molecules, such as 2c, 2f, and 4a. The introduction of the terminal-end amine succeeded in maintaining the in vitro activities at sub-nanomolar levels. The vivo activities could be greatly affected by variations in the two amines via modulating the metabolic stability and lipophilicity of the compounds.