312936-77-9 Usage
Description
1-(4-Bromobenzyl)-2-mercapto-5-hydroxymethylimidazole is a chemical compound belonging to the imidazole class, characterized by its molecular formula C10H10BrN3OS. 1-(4-BroMobenzyl)-2-Mercapto-5-hydroxyMethyliMidazole features a benzyl group, a bromine atom, a thiol group, and a hydroxymethyl group, which contribute to its unique structure and properties. It is widely utilized in research and pharmaceutical applications, particularly in the development of drugs targeting the adenosine receptor.
Uses
Used in Pharmaceutical Applications:
1-(4-Bromobenzyl)-2-mercapto-5-hydroxymethylimidazole is used as a key compound in the development of drugs targeting the adenosine receptor for various therapeutic applications. Its unique structure allows for the modulation of adenosine receptor activity, which can lead to the development of new treatments for conditions such as asthma, chronic obstructive pulmonary disease (COPD), and other respiratory disorders.
Used in Research:
In the research industry, 1-(4-Bromobenzyl)-2-mercapto-5-hydroxymethylimidazole serves as a valuable tool for studying biochemical processes and the role of adenosine receptors in various physiological and pathological conditions. Its unique properties make it an essential component in the design and synthesis of novel compounds with potential therapeutic applications.
Used in Drug Development:
1-(4-Bromobenzyl)-2-mercapto-5-hydroxymethylimidazole is employed as a building block in the synthesis of new drug candidates targeting adenosine receptors. Its versatile structure enables the development of compounds with improved pharmacological properties, such as enhanced selectivity, potency, and bioavailability, which are crucial for the success of new therapeutic agents in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 312936-77-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,2,9,3 and 6 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 312936-77:
(8*3)+(7*1)+(6*2)+(5*9)+(4*3)+(3*6)+(2*7)+(1*7)=139
139 % 10 = 9
So 312936-77-9 is a valid CAS Registry Number.
312936-77-9Relevant articles and documents
Triazole derivatives: A series of Darapladib analogues as orally active Lp-PLA2 inhibitors
Wang, Kai,Xu, Wenwei,Zhang, Wei,Mo, Mingguang,Wang, Yiping,Shen, Jianhua
supporting information, p. 2897 - 2901 (2013/06/26)
This Letter reports our efforts towards the optimization of our previously identified series of imidazole and triazole derivatives that lead to the discovery of a series of orally active Lp-PLA2 inhibitors in C57 mice. These inhibitors are characterized by the presence of a diamine side chain in the molecules, such as 2c, 2f, and 4a. The introduction of the terminal-end amine succeeded in maintaining the in vitro activities at sub-nanomolar levels. The vivo activities could be greatly affected by variations in the two amines via modulating the metabolic stability and lipophilicity of the compounds.
Process for making 1,5-disubstituted imidazoles
-
, (2008/06/13)
The present invention is directed to a process for synthesizing 1,5-disubstituted imidazoles, which are useful in the preparation of farnesyl-protein transferase inhibitors.
