143360-93-4

Basic information

• Product Name: AcetaMide, N-(2-ethynylphenyl)-2,2,2-trifluoro-
• Synonyms: AcetaMide, N-(2-ethynylphenyl)-2,2,2-trifluoro-
• CAS NO: 143360-93-4
• Molecular Formula: C₁₀H₆F₃NO
• Molecular Weight: 213.1559496
• Mol File: 143360-93-4.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: AcetaMide, N-(2-ethynylphenyl)-2,2,2-trifluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: AcetaMide, N-(2-ethynylphenyl)-2,2,2-trifluoro-(143360-93-4)
• EPA Substance Registry System: AcetaMide, N-(2-ethynylphenyl)-2,2,2-trifluoro-(143360-93-4)

Safety Data

• Hazardous Substances Data: 143360-93-4(Hazardous Substances Data)

Upstream product

• 52670-38-9 2-ethynylaniline 
• 407-25-0 trifluoroacetic anhydride 
• 615-43-0 2-iodophenylamine 
• 1066-54-2 trimethylsilylacetylene 
• 143321-89-5 2,2,2-trifluoro-N-(2-iodophenyl)acetamide 
• 103529-16-4 2-[(trimethylsilyl)ethynyl]aniline 

Downstream Products

• 143360-90-1 2-(cyclooct-1-enyl)ethynyltrifluoroacetanilide 
• 155335-21-0 2-(3-methylphenyl)ethynyltrifluoroacetanilide 
• 143360-91-2 2-(6-methoxy-3,4-dihydro-1-naphthyl)ethynyltrifluoroacetanilide 
• 143360-92-3 2,2,2-Trifluoro-N-[2-(4-phenyl-cyclohex-1-enylethynyl)-phenyl]-acetamide 
• 120-72-9 indole 
• 1504-16-1 3-phenyl-1H-indole 
• 62236-80-0 3-(4-chlorophenyl)-1H-indole 
• 101125-32-0 3-(4-fluorophenyl)-1H-indole 
• 201813-48-1 N-{2-[(4-acetylphenyl)ethynyl]phenyl}-2,2,2-trifluoroacetamide 
• 30015-86-2 3-(4-methylphenyl)-1H-indole 
• 5782-23-0 3-(4-methoxy-phenyl)-1H-indole 

Relevant articles and documents

Sequential Sonogashira/intramolecular aminopalladation/cross-coupling ofortho-ethynyl-anilines catalyzed by a single palladium source: rapid access to 2,3-diarylindoles

We have developed a practical and efficient one-pot protocol for the synthesis of 2,3-diarylindolesviaPd-catalyzed bis-arylative cyclization of variouso-ethynylanilines with aryl iodides. Mechanism studies showed that a Pd-catalyzed Sonogashira reaction took place firstly, giving an internal alkyne intermediate, which subsequently underwent intramolecular aminopalladation/cross-coupling to give access to 2,3-diarylindoles. The present methodology exhibits a broad substrate scope, producing various 2,3-diaryl indoles bearing two different aryl groups.

Investigation of the intermolecular Pauson-Khand reaction of various 1-alkynes with cyclic exo-methylene compounds

Intermolecular Pauson-Khand reaction of various 1-alkynes with 4-exo-methylenepiperidine and -cyclohexane derivatives to give corresponding spirocyclopentenones was investigated. The reaction of m- and p-substituted arylalkynes furnished corresponding spirocyclic compounds in good yields, while that of o-substituted arylalkynes and 1-hexyne proceeded in nil to moderate yield.

C(2)-(α-Mannosyl)indole: The pivotal intermediate towards the natural C-Glycopeptides

Two different approaches were investigated to prepare the unusual modified peptide C(2)-mannosylated indole residue. Direct glycosylation of 2-metallated indoles or 2-trimethylsilylindole derivative by reaction with perbenzylated α-D-mannopyranosyl bromid