62236-80-0

Basic information

• Product Name: 3-(4-CHLOROPHENYL)INDOLE
• Synonyms: 3-(4-CHLOROPHENYL)INDOLE
• CAS NO: 62236-80-0
• Molecular Formula: C₁₄H₁₀ClN
• Molecular Weight: 227.69
• Mol File: 62236-80-0.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-CHLOROPHENYL)INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-CHLOROPHENYL)INDOLE(62236-80-0)
• EPA Substance Registry System: 3-(4-CHLOROPHENYL)INDOLE(62236-80-0)

Safety Data

• Hazardous Substances Data: 62236-80-0(Hazardous Substances Data)

Upstream product

• 637-87-6 1-Chloro-4-iodobenzene 
• 143360-93-4 N-(2-ethynylphenyl)-2,2,2-trifluoroacetamide 
• 120-72-9 indole 
• 106-39-8 bromochlorobenzene 
• 2788-86-5 4-Chlorostyrene oxide 
• 100-63-0 phenylhydrazine 
• 1073-69-4 N-4-chlorophenylhydrazine 
• 106-47-8 4-chloro-aniline 
• 4251-65-4 (4-chlorophenyl)acetaldehyde 
• 1875-88-3 2-(4-Chlorophenyl)ethanol 
• 59-88-1 phenylhydrazine hydrochloride 
• 33984-97-3 trans-2,3-epoxy-3-(4-chlorophenyl)propanenitrile 
• 104-88-1 4-chlorobenzaldehyde 
• 3169-61-7 2-[1-(4-chlorophenyl)ethenyl]benzenamine 

Relevant articles and documents

Pd/β-cyclodextrin-catalyzed C-H functionalization in water: A greener approach to regioselective arylation of (NH)-indoles with aryl bromides

A greener and more practical strategy for the site-selective C-H arylation of (NH)-indoles via coupling of (hetero)aryl bromides was developed, in which β-cyclodextrin, acting as both a ligand for Na2PdCl4 and a host for indoles, enables the reactions to occur easily in water. The key advantage of this method is the ingenious merging of aqueous homogeneous catalysis and ligand mediation, leading to the highly regioselective formation of C3-arylindoles with a broad substrate scope and functional-group tolerance. Moreover, the regioselectivity can be switched from the C3 to the C2-position by varying the nature of the base without recourse to employing ArI as substrates.

Regiospecificity in Ligand-Free Pd-Catalyzed C-H Arylation of Indoles: LiHMDS as Base and Transient Directing Group

A highly efficient catalyst-base pair for the C-H arylation of free (NH)-indoles in the C-3 position is reported. Ligand-free palladium acetate coupled with lithium hexamethyldisilazide (LiHMDS) catalyzed the regiospecific, i.e. 100% regioselective, C-3 a

Iron-Promoted Construction of Indoles via Intramolecular Oxidative C-N Coupling of 2-Alkenylanilines Using Persulfate

Indole scaffold synthesis relies primarily on oxidative C-H amination of N-protected alkenylanilines for C-N intramolecular cyclization reactions. Herein, for the first time, without N-protection, various readily prepared 2-alkenylanilines were transformed into the desired indole products in good yields by using K 2 S 2 O 8 as oxidant in the presence of catalytic amounts of FeF 2. The K 2 S 2 O 8 /FeF 2 system offers a direct and benign synthetic route to 3-arylindoles and it is applicable to a wide range of substituted indoles including drug intermediates.