1434302-11-0

Basic information

• Product Name: (2S,4S)-benzyl 2-(bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl)-4-hydroxypyrrolidine-1-carboxylate
• Synonyms: (2S,4S)-benzyl 2-(bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl)-4-hydroxypyrrolidine-1-carboxylate
• CAS NO: 1434302-11-0
• Molecular Weight: 675.471
• Mol File: 1434302-11-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,4S)-benzyl 2-(bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl)-4-hydroxypyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4S)-benzyl 2-(bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl)-4-hydroxypyrrolidine-1-carboxylate(1434302-11-0)
• EPA Substance Registry System: (2S,4S)-benzyl 2-(bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl)-4-hydroxypyrrolidine-1-carboxylate(1434302-11-0)

Safety Data

• Hazardous Substances Data: 1434302-11-0(Hazardous Substances Data)

Upstream product

• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 328-70-1 3,6-bis(trifluoromethyl)bromobenzene 
• 80986-14-7 5-aza-5-carbobenzoxy-2-oxa-3-oxo-bicyclo<2.2.1>heptane 

Downstream Products

• 1434302-14-3 (1S,6S)-benzyl 5,5-bis(3,5-bis(trifluoromethyl)phenyl)-3,3-dimethyl-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane-7-carboxylate 

Relevant articles and documents

A new family of conformationally constrained bicyclic diarylprolinol silyl ethers as organocatalysts

Simple chemical manipulations of trans-4-L-hydroxy proline allow the access to a new family of bicyclic silyl ether organocatalysts that display some remarkable features. Apart from being extremely stable to hydrolytic conditions and possessing excellent catalytic performances, the rigidity of the bicyclic structure imposes a synclinal endo disposition of the bulky substituents with respect to the pyrrolidine ring, opposed to the more stable synclinal exo conformations of Jorgensen-Hayashi catalysts.