80986-14-7

Basic information

• Product Name: 5-aza-5-carbobenzoxy-2-oxa-3-oxo-bicyclo<2.2.1>heptane
• Synonyms: 5-aza-5-carbobenzoxy-2-oxa-3-oxo-bicyclo<2.2.1>heptane
• CAS NO: 80986-14-7
• Molecular Weight: 247.251
• Mol File: 80986-14-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5-aza-5-carbobenzoxy-2-oxa-3-oxo-bicyclo<2.2.1>heptane(CAS DataBase Reference)
• NIST Chemistry Reference: 5-aza-5-carbobenzoxy-2-oxa-3-oxo-bicyclo<2.2.1>heptane(80986-14-7)
• EPA Substance Registry System: 5-aza-5-carbobenzoxy-2-oxa-3-oxo-bicyclo<2.2.1>heptane(80986-14-7)

Safety Data

• Hazardous Substances Data: 80986-14-7(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 13504-86-4 (2S,4S)-1-benzyloxycarbonyl-4-hydroxyproline 
• 538-75-0 dicyclohexyl-carbodiimide 
• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 64187-47-9 1-benzyloxycarbonyl-4-keto-L-proline 

Downstream Products

• 1434302-10-9 (2S,4S)-benzyl 4-hydroxy-2-(hydroxydiphenylmethyl)pyrrolidine-1-carboxylate 
• 1434302-12-1 (2S,4S)-benzyl 4-hydroxy-2-(hydroxydi(naphthalen-2-yl)methyl)pyrrolidine-1-carboxylate 
• 1434302-11-0 (2S,4S)-benzyl 2-(bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl)-4-hydroxypyrrolidine-1-carboxylate 
• 1434302-13-2 (1S,6S)-benzyl 3,3-dimethyl-5,5-diphenyl-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane-7-carboxylate 
• 1434302-16-5 (1S,6S)-benzyl 3,3-dimethyl-5,5-di(naphthalen-2-yl)-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane-7-carboxylate 
• 1434302-19-8 (1S,6S)-3,3,5,5-tetraphenyl-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane 
• 194933-40-9 (2S,4S)-4-(tert-Butyl-dimethyl-silanyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-pentafluorophenyl ester 
• 194933-41-0 (2S,4S)-4-(tert-Butyl-dimethyl-silanyloxy)-2-((S)-2-methyl-5-oxo-pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 194933-51-2 (2S,4S)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-1,2-dicarboxylic acid 1-benzyl-2-methyl 
• 165177-74-2 (4S)-1-benzyloxycarbonyl-4-(t-butyldimethylsilyloxy)-L-proline 
• 866101-89-5 (2S,4S)-4-(tert-Butyl-dimethyl-silanyloxy)-2-((R)-2-methyl-5-oxo-pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 57653-35-7 (2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylic acid 1-benzyl 2-methyl 

Relevant articles and documents

New chiral proline-based catalysts for silicon and zirconium oxides-promoted asymmetric Biginelli reaction

[Figure not available: see fulltext.] 4-Hydroxy-(2S)-prolines bearing 3,4-dihydro-2H-1,4-benzoxazine or 1,2,3,4-tetrahydroquinoline fragments were synthesized and studied as chiral catalysts in the Biginelli reaction. The target product ethyl 6-methyl-2-o

A new family of conformationally constrained bicyclic diarylprolinol silyl ethers as organocatalysts

Simple chemical manipulations of trans-4-L-hydroxy proline allow the access to a new family of bicyclic silyl ether organocatalysts that display some remarkable features. Apart from being extremely stable to hydrolytic conditions and possessing excellent catalytic performances, the rigidity of the bicyclic structure imposes a synclinal endo disposition of the bulky substituents with respect to the pyrrolidine ring, opposed to the more stable synclinal exo conformations of Jorgensen-Hayashi catalysts.

A SHORT IMPROVED SYSTHESIS OF N-SUBSTITUTED 5-AZA-2-OXA-3-OXO-BICYCLOHEPTANES

N-Substituted 5-aza-2-oxa-3-oxo-bicycloheptanes are conformationally rigid models that have been used in several 1H-NMR studies.They have previously been obtained by multistep processes.We have devised a one step synthesis for these compounds.The utility of this new route has been demonstrated for five differently N-substituted substrates.