1436849-34-1

Basic information

• Product Name: 3-methyl-N-(quinolin-8-yl)-[1,1′-biphenyl]-2-carboxamide
• Synonyms: 3-methyl-N-(quinolin-8-yl)-[1,1′-biphenyl]-2-carboxamide
• CAS NO: 1436849-34-1
• Molecular Weight: 338.409
• Mol File: 1436849-34-1.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 3-methyl-N-(quinolin-8-yl)-[1,1′-biphenyl]-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-N-(quinolin-8-yl)-[1,1′-biphenyl]-2-carboxamide(1436849-34-1)
• EPA Substance Registry System: 3-methyl-N-(quinolin-8-yl)-[1,1′-biphenyl]-2-carboxamide(1436849-34-1)

Safety Data

• Hazardous Substances Data: 1436849-34-1(Hazardous Substances Data)

Upstream product

• 108-86-1 bromobenzene 
• 1182669-71-1 N-(2-methylbenzoyl)-8-aminoquinoline 
• 933-88-0 ortho-toluoyl chloride 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 578-66-5 8-amino quinoline 
• 118-90-1 ortho-methylbenzoic acid 
• 455-32-3 benzoyl fluoride 
• 65-85-0 benzoic acid 
• 2996-92-1 phenyl trimethylsiloxane 
• 3262-89-3 triphenylboroxine 
• 98-80-6 phenylboronic acid 
• 591-50-4 iodobenzene 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 1623774-99-1 N-(2-(1-benzyl-1H-1, 2, 3-triazol-4-yl)propan-2-yl)-2-methylbenzamide 

Relevant articles and documents

Aryne Multicomponent Reactions by Directed C?H Activation

Arylation via ortho C?H activation by the aid of directing groups has been explored recently by many researchers. Herein, a palladium-catalyzed C?H arylation using 8-aminoquinoline as a bidentate directing group has been developed. The reaction furnishes only C?H arylation, unlike previous methods where cyclization to corresponding isoquinolones is observed. More interestingly, sequential C?H functionalization was observed when methylacrylate and acrylonitrile was added; this led to C?H olefination with the aryl group, which was installed from the aryne precursor.

A facile method for Rh-catalyzed decarbonylativeortho-C-H alkylation of (hetero)arenes with alkyl carboxylic acids

A facile and effective method for Rh-catalyzed directortho-alkylation of C-H bonds in (hetero)arenes with commercially available carboxylic acids has been developed. This strategy was initiated byin situconversion of carboxylic acids to anhydrides which, without isolation, underwent Rh-catalyzed direct decarbonylative cross-coupling of aryl carboxamides containing 8-aminoquinoline. The reaction proceeds with high regioselectivity and exhibits a broad substrate scope as well as functional group tolerance.

Copper-Mediated ortho-Arylation of Benzamides with Arylboronic Acid

The copper-mediated direct ortho C-H bond arylation of benzamide derivatives with arylboronic acids was achieved by employing an 8-aminoquinoline moiety as the bidentate directing group. Various biaryls were synthesized in good yields with excellent regioselectivity. The reaction shows good functional group compatibility and proceeds in a highly selective manner at the ortho-position of the benzamides. Deuterium-labelling experiments indicated that the ortho C-H bond cleavage of benzamide was involved in the rate-determining step of the arylation.