1623774-99-1Relevant articles and documents
MnCl2-Catalyzed C?H Alkylations with Alkyl Halides
Liu, Weiping,Cera, Gianpiero,Oliveira, Jo?o C. A.,Shen, Zhigao,Ackermann, Lutz
supporting information, p. 11524 - 11528 (2017/08/30)
C?H alkylations with challenging β-hydrogen-containing alkyl halides were accomplished with sustainable MnCl2 as the catalyst under phosphine-ligand-free conditions. The proximity-induced benzamide C?H activation occurred with ample substrate s
Expedient Iron-Catalyzed C-H Allylation/Alkylation by Triazole Assistance with Ample Scope
Cera, Gianpiero,Haven, Tobias,Ackermann, Lutz
, p. 1484 - 1488 (2016/02/12)
Triazole assistance set the stage for a unified strategy for the iron-catalyzed C-H allylation of arenes, heteroarenes, and alkenes with ample scope. The versatile catalyst also proved competent for site-selective methylation, benzylation, and alkylation with challenging primary and secondary halides. Triazole-assisted C-H activation proceeded chemo-, site-, and diastereo-selectively, and the modular TAM directing group was readily removed in a traceless fashion under exceedingly mild reaction conditions. One for all: A unified strategy for iron-catalyzed C-H allylation and alkylation was developed by the use of a triazole directing group that could be cleaved under exceedingly mild conditions.
Triazole-assisted ruthenium-catalyzed C-H arylation of aromatic amides
Al Mamari, Hamad H.,Diers, Emelyne,Ackermann, Lutz
, p. 9739 - 9743 (2014/08/18)
Site-selective ruthenium(II)-catalyzed direct arylation of amides was achieved through C-H cleavages with modular auxiliaries, derived from easily accessible 1,2,3-triazoles. The triazolyldimethylmethyl (TAM) bidentate directing group was prepared in a highly modular fashion through copper(I)-catalyzed 1,3-dipolar cycloaddition and allowed for ruthenium-catalyzed C-H arylations on arenes and heteroarenes, as well as alkenes, by using easy-to-handle aryl bromides as the arylating reagents. The triazole-assisted C-H activation strategy was found to be widely applicable, to occur under mild reaction conditions, and the catalytic system was tolerant of important electrophilic functionalities. Notably, the flexible triazole-based auxiliary proved to be a more potent directing group for the optimized ruthenium(II)-catalyzed direct arylations, compared with pyridyl-substituted amides or substrates derived from 8-aminoquinoline. Assisting activation: Ruthenium(II)-catalyzed C-H arylations of (hetero)arenes and alkenes have been achieved with aryl halides through removable bidentate auxiliaries derived from modular 1,2,3-triazoles (see scheme; TAM=triazolyldimethylmethyl).
