1646183-95-0

Basic information

• Product Name: ethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-3’-methyl-[1,1’-biphenyl]-4-carboxylate
• Synonyms: ethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-3’-methyl-[1,1’-biphenyl]-4-carboxylate
• CAS NO: 1646183-95-0
• Molecular Weight: 482.582
• Mol File: 1646183-95-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-3’-methyl-[1,1’-biphenyl]-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-3’-methyl-[1,1’-biphenyl]-4-carboxylate(1646183-95-0)
• EPA Substance Registry System: ethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-3’-methyl-[1,1’-biphenyl]-4-carboxylate(1646183-95-0)

Safety Data

• Hazardous Substances Data: 1646183-95-0(Hazardous Substances Data)

Upstream product

• 933-88-0 ortho-toluoyl chloride 
• 118-90-1 ortho-methylbenzoic acid 
• 622-79-7 benzyl azide 
• 2978-58-7 1,1-dimethylprop-3-ynylamine 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 1623774-99-1 N-(2-(1-benzyl-1H-1, 2, 3-triazol-4-yl)propan-2-yl)-2-methylbenzamide 
• 1310826-33-5 2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-amine 

Relevant articles and documents

Triazole-assisted ruthenium-catalyzed C-H arylation of aromatic amides

Site-selective ruthenium(II)-catalyzed direct arylation of amides was achieved through C-H cleavages with modular auxiliaries, derived from easily accessible 1,2,3-triazoles. The triazolyldimethylmethyl (TAM) bidentate directing group was prepared in a highly modular fashion through copper(I)-catalyzed 1,3-dipolar cycloaddition and allowed for ruthenium-catalyzed C-H arylations on arenes and heteroarenes, as well as alkenes, by using easy-to-handle aryl bromides as the arylating reagents. The triazole-assisted C-H activation strategy was found to be widely applicable, to occur under mild reaction conditions, and the catalytic system was tolerant of important electrophilic functionalities. Notably, the flexible triazole-based auxiliary proved to be a more potent directing group for the optimized ruthenium(II)-catalyzed direct arylations, compared with pyridyl-substituted amides or substrates derived from 8-aminoquinoline. Assisting activation: Ruthenium(II)-catalyzed C-H arylations of (hetero)arenes and alkenes have been achieved with aryl halides through removable bidentate auxiliaries derived from modular 1,2,3-triazoles (see scheme; TAM=triazolyldimethylmethyl).