1623775-22-3

Basic information

• Product Name: N-(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)-3,4'-dimethyl-[1,1'-biphenyl]-2-carboxamide
• Synonyms: N-(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)-3,4'-dimethyl-[1,1'-biphenyl]-2-carboxamide
• CAS NO: 1623775-22-3
• Molecular Weight: 424.546
• Mol File: 1623775-22-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)-3,4'-dimethyl-[1,1'-biphenyl]-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)-3,4'-dimethyl-[1,1'-biphenyl]-2-carboxamide(1623775-22-3)
• EPA Substance Registry System: N-(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)-3,4'-dimethyl-[1,1'-biphenyl]-2-carboxamide(1623775-22-3)

Safety Data

• Hazardous Substances Data: 1623775-22-3(Hazardous Substances Data)

Upstream product

• 624-31-7 4-tolyl iodide 
• 1623774-99-1 N-(2-(1-benzyl-1H-1, 2, 3-triazol-4-yl)propan-2-yl)-2-methylbenzamide 
• 933-88-0 ortho-toluoyl chloride 
• 118-90-1 ortho-methylbenzoic acid 
• 106-38-7 para-bromotoluene 
• 1310826-33-5 2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-amine 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 2978-58-7 1,1-dimethylprop-3-ynylamine 
• 622-79-7 benzyl azide 

Relevant articles and documents

Palladium-Catalyzed C–H Arylation of Amides by Triazole Assistance

Versatile palladium-catalyzed C–H arylations of benzamides were accomplished with the assistance of a removable triazole amine (TAM). The robustness of the palladium-catalyzed C–H functionalization protocol is reflected in its broad functional group tolerance, ample substrate scope, and ability to proceed under silver-free reaction conditions.

Iron-catalyzed C(sp2)-H and C(sp3)-H arylation by triazole assistance

Modular 1,2,3-triazoles enabled iron-catalyzed C-H arylations with broad scope. The novel triazole-based bidentate auxiliary is easily accessible in a highly modular fashion and allowed for user-friendly iron-catalyzed C(sp 2)-H functionalizations of arenes and alkenes with excellent chemo- and diastereoselectivities. The versatile iron catalyst also proved applicable for challenging C(sp3)-H functionalizations, and proceeds by an organometallic mode of action. The triazole-assisted C-H activation strategy occurred under remarkably mild reaction conditions, and the auxiliary was easily removed in a traceless fashion. Intriguingly, the triazole group proved superior to previously used auxiliaries. With a little help: A versatile iron catalyst allows the arylation of C(sp2)-H and C(sp3)-H bonds in the presence of a modular and removable triazolyldimethylmethyl (TAM) auxiliary, whose structure can be varied through 1,3-dipolar azide-alkyne cycloadditions.