143774-66-7

Basic information

• Product Name: 1H-Indole-2-methanol, 3-methyl-a-phenyl-1-(phenylsulfonyl)-
• CAS NO: 143774-66-7
• Molecular Formula: C22H19NO3S
• Molecular Weight: 377.464
• Mol File: 143774-66-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Indole-2-methanol, 3-methyl-a-phenyl-1-(phenylsulfonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-2-methanol, 3-methyl-a-phenyl-1-(phenylsulfonyl)-(143774-66-7)
• EPA Substance Registry System: 1H-Indole-2-methanol, 3-methyl-a-phenyl-1-(phenylsulfonyl)-(143774-66-7)

Safety Data

• Hazardous Substances Data: 143774-66-7(Hazardous Substances Data)

Upstream product

• 108-86-1 bromobenzene 
• 110396-65-1 3-methyl-1-(phenylsulfonyl)-1H-indole-2-carbaldehyde 
• 83-34-1 3-Methylindole 
• 58550-84-8 N-(phenylsulphonyl)-3-methylindole 
• 100-52-7 benzaldehyde 

Downstream Products

• 95816-67-4 bis(3-methylindolyl)phenylmethane 
• 143774-67-8 2-benzoyl-3-(bromomethyl)-1-(phenylsulfonyl)indole 
• 143774-68-9 2-benzoyl-3-(hydroxymethyl)-1-(phenylsulfonyl)indole 
• 143774-52-1 3-phenyl-4-(phenylsulfonyl)-4H-furo<3,4-b>indole 
• 77507-53-0 (3-methyl-1-(phenylsulfonyl)-1H-indol-2-yl)(phenyl)methanone 

Relevant articles and documents

Cu(OTf)2 catalysed [6+2] cycloaddition reaction for the synthesis of highly substituted pyrrolo[1,2-a]indoles: Rapid construction of the yuremamine core

Lewis acid catalysed [6+2] cycloaddition reaction for the synthesis of pyrrolo[1,2-a]indoles generating three contiguous stereocenters in a highly regio- and diastereoselective manner has been developed and further applied for the construction of the fully functionalized tricyclic core of yuremamine.

Magnesiation of indoles with magnesium amide bases

1-Substituted indole derivatives are deprotonated with Hauser bases (R2NMgBr) or magnesium diamide [(R2N)2-Mg] to give magnesioindoles which are then reacted with electrophiles.