1437793-93-5

Basic information

• Product Name: 2-(4-(tert-butyl)phenyl)-1-methyl-1H-benzo[d]imidazole
• Synonyms: 2-(4-(tert-butyl)phenyl)-1-methyl-1H-benzo[d]imidazole
• CAS NO: 1437793-93-5
• Molecular Weight: 264.37
• Mol File: 1437793-93-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(4-(tert-butyl)phenyl)-1-methyl-1H-benzo[d]imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(tert-butyl)phenyl)-1-methyl-1H-benzo[d]imidazole(1437793-93-5)
• EPA Substance Registry System: 2-(4-(tert-butyl)phenyl)-1-methyl-1H-benzo[d]imidazole(1437793-93-5)

Safety Data

• Hazardous Substances Data: 1437793-93-5(Hazardous Substances Data)

Upstream product

• 1632-83-3 1-Methylbenzimidazole 
• 5396-38-3 1-(tert-butyl)-4-methoxybenzene 
• 939-97-9 4-tert-Butylbenzaldehyde 
• 25148-68-9 N-methylbenzene-1,2-diamine dihydrochloride 
• 39895-55-1 4-(1,1-dimethylethyl)-benzenemethanamine 
• 4760-34-3 N-methyl-1,2-phenylenediamine 

Relevant articles and documents

Nickel-Catalyzed Heteroarenes Cross Coupling via Tandem C-H/C-O Activation

Inert aryl methyl ethers as coupling components via C-O activation have been established with a Ni catalyst for C-H activation of heteroarene. The key to simultaneous C-H/C-O bond activation is the use of sterically demanding o-tolylMgBr. The protocol is effective for a wide scope of substrates including naphthyl methyl ethers, anisoles, and a variety of other heteroarene derivatives. Detailed mechanistic studies indicated that the C-O cleavage is assisted via synergistic effect of nickel and Grignard reagent in this C-H/C-O reaction, which is supported by DFT calculation. At this stage, single-electron transfer can be ruled out as a main operative process for this tandem strategy.

Catalytic Oxidative Coupling of Primary Amines under Air: A Flexible Route to Benzimidazole Derivatives

Benzimidazoles are of fundamental importance in chemistry and biology, and the development of efficient, environmentally benign methods for their preparation remains a key challenge for organic chemists. In a biomimetic approach inspired by copper amine oxidases, we disclose herein the scope and factors influencing the success of the cooperative action of CuBr2 as electron-transfer mediator and a topaquinone-like substrate-selective catalyst in the oxidative cyclocondensation of primary amines with o-aminoanilines. This one-pot atom-economic multistep process, which works under green conditions with ambient air as the terminal oxidant, low loadings of catalyst, and equimolar amounts of commercially available amine substrates, is particularly suitable for the preparation of 1,2-disubstituted benzimidazoles. Furthermore, it allows the functionalization of nonactivated primary aliphatic amines, which are known to be challenging substrates for non-enzymatic catalytic aerobic systems.