14378-08-6

Basic information

• Product Name: (E)-2-cyano-3-(4-methoxyphenyl)acrylic acid
• Synonyms: (E)-2-cyano-3-(4-methoxyphenyl)acrylic acid
• CAS NO: 14378-08-6
• Molecular Weight: 203.197
• Mol File: 14378-08-6.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: (E)-2-cyano-3-(4-methoxyphenyl)acrylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-cyano-3-(4-methoxyphenyl)acrylic acid(14378-08-6)
• EPA Substance Registry System: (E)-2-cyano-3-(4-methoxyphenyl)acrylic acid(14378-08-6)

Safety Data

• Hazardous Substances Data: 14378-08-6(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 372-09-8 cyanoacetic acid 
• 135-02-4 ortho-anisaldehyde 
• 142-08-5 2-Pyridone 
• 154198-90-0 (E)-3-p-anisyl-2-cyano-2-propenoyl azide 
• 27888-23-9 (E)-3-p-anisyl-2-cyano-2-propenoyl chloride 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 80540-67-6 p-nitrophenyl 2-cyano-3-(p-methoxyphenyl)propenoate 
• 27888-23-9 (E)-3-p-anisyl-2-cyano-2-propenoyl chloride 
• 31007-06-4 2-(4-methoxyphenyl)propionitrile 
• 1352550-07-2 methyl N-[(E)-2-cyano-3-(4-methoxyphenyl)prop-2-enoyl]-L-serinate 
• 1352550-08-3 N₂-[(E)-2-cyano-3-(4-methoxyphenyl)prop-2-enoyl]-N₁-cyclopropyl-L-serinamide 
• 36397-19-0 α-Cyano-β-(4-methoxyphenyl)propionic acid 
• 5349-42-8 (5Z)-5-(4-methoxybenzylidene)imidazolidine-2,4-dione 
• 154199-10-7 [1-Cyano-2-(4-methoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 154199-09-4 2-Cyano-3-(4-methoxy-phenyl)-propionyl azide 
• 154198-90-0 (E)-3-p-anisyl-2-cyano-2-propenoyl azide 

Relevant articles and documents

Enhanced antioxidation capacity endowed to a mixed type aldose reductase inhibitor leads to a promising anti-diabetic complications agent

A series of 5f-based new compounds has been designed and synthesized. In vitro screening demonstrated that the binding affinity and selectivity on aldose reductase (AR) were positively correlated with its antioxidation capacity. Compound 6d was verified t

Synthesis and biological evaluation of bifendate derivatives bearing acrylamide moiety as novel antioxidant agents

Oxidative stress plays a significant role in the pathogenesis of various human diseases. In this study, a series of bifendate derivatives bearing acrylamide moiety were synthesized and evaluated as anti-oxidant agents. Biological evaluation indicated that

Arylcyanoacrylamides as inhibitors of the Dengue and West Nile virus proteases

The 3-aryl-2-cyanoacrylamide scaffold was designed as core pharmacophore for inhibitors of the Dengue and West Nile virus serine proteases (NS2B-NS3). A total of 86 analogs was prepared to study the structure-activity relationships in detail. Thereby, it turned out that the electron density of the aryl moiety and the central double bond have a crucial influence on the activity of the compounds, whereas the influence of substituents of the amide residue is less relevant. The para-hydroxy substituted analog was found to be the most potent inhibitor in this series with a Ki-value of 35.7 μM at the Dengue and 44.6 μM at the West Nile virus protease. The aprotinin competition assay demonstrates a direct interaction of the inhibitor molecule with active centre of the Dengue virus protease. The target selectivity was studied in a counterscreen with thrombin and found to be 2.8:1 in favor of DEN protease and 2.3:1 in favor of WNV protease, respectively.