143878-24-4

Basic information

• Product Name: 4-Acetylamino-5-chloro-2-hydroxy-3-iodobenzoic acid methyl ester
• Synonyms: 4-Acetylamino-5-chloro-2-hydroxy-3-iodobenzoic acid methyl ester;Methyl 4-acetamido-5-chloro-2-hydroxy-3-iodobenzoate
• CAS NO: 143878-24-4
• Molecular Formula: C₁₀H₉ClINO₄
• Molecular Weight: 369.54
• Mol File: 143878-24-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Acetylamino-5-chloro-2-hydroxy-3-iodobenzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Acetylamino-5-chloro-2-hydroxy-3-iodobenzoic acid methyl ester(143878-24-4)
• EPA Substance Registry System: 4-Acetylamino-5-chloro-2-hydroxy-3-iodobenzoic acid methyl ester(143878-24-4)

Safety Data

• Hazardous Substances Data: 143878-24-4(Hazardous Substances Data)

Usage

General Description

"4-Acetylamino-5-chloro-2-hydroxy-3-iodobenzoic acid methyl ester" is a chemical compound containing acetylamino, chloro, hydroxy, and iodobenzoic acid groups. It is an organic compound with a methyl ester functional group. 4-Acetylamino-5-chloro-2-hydroxy-3-iodobenzoic acid methyl ester has potential applications in the pharmaceutical industry, especially in the synthesis of new drugs and medications. Its specific properties and potential uses can vary depending on the specific structure and context in which it is employed. Overall, "4-Acetylamino-5-chloro-2-hydroxy-3-iodobenzoic acid methyl ester" is a versatile chemical compound with various potential applications.

Upstream product

• 24190-77-0 methyl 4-acetylamino-5-chloro-2-hydroxybenzoate 
• 4093-28-1 methyl 4-acetamido-2-hydroxybenzoate 
• 65-49-6 4-Aminosalicylic acid 
• 4136-97-4 methyl 4-aminosalicylate 

Downstream Products

• 179872-37-8 4-Acetylamino-5-chloro-3-iodo-2-methoxy-benzoic acid methyl ester 
• 179872-39-0 4-amino-5-chloro-3-iodo-2-methoxybenzoic acid 
• 179872-38-9 4-acetylamino-5-chloro-3-iodo-2-methoxybenzoic acid 
• 1198572-92-7 C₁₃H₁₄ClNO₅ 
• 1198572-93-8 C₁₃H₁₄ClNO₅ 
• 935696-96-1 4-amino-5-chlorobenzofuran-7-carboxylic acid 

Relevant articles and documents

Preparation method of key intermediate 4-amino-5-halobenzofuran-7-carboxylic acid of 5-HT4 receptor stimulant

The invention discloses a preparation method of a key intermediate 4-amino-5-halobenzofuran-7-carboxylic acid of a 1,5-HT4 receptor stimulant, belonging to the field of organic synthesis. According tothe preparation method, para-protected amino-o-hydroxybenzoic acid/hydroxybenzoate, a halogenating reagent and triethyl acetenyl silicon are used as main raw materials, and a three-step reaction is performed to obtain the 4-amino-5-halobenzofuran-7-carboxylic acid. The method has the advantages of simple process operation, short reaction steps, easy separation of the intermediate, total yield ofmore than 51%, usage cheap and easily available raw materials and greatly reduced production cost; and thus, the method has obvious competitive advantages.

NOVEL COMPOUND

The present invention relates to a novel benzofuran carboxamide derivative having pharmacological activity, to processes for its preparation, to compositions containing it and to its use in the treatment of diseases treatable by 5-HT4 agonism.

Process for the preparation of substituted benzofuran derivatives

Substituted benzofuran derivatives of the formula (I): STR1 wherein one of R1 and R2 is hydrogen or halogen and the other is, independently, an amino group or a C2 -C4 alkanoyl amino group; R3 is hydrogen; a linear or branched C1 -C4 alkyl, C1 -C4 alkoxy or C2 -C4 alkoxycarbonyl group; halogen; or phenyl unsubstituted or substituted by a C1 -C4 alkyl group; A is a group --(CH2)n -Het wherein Het is an optionally substituted heteromonocyclic or heterobicyclic ring containing one or two nitrogen atoms, and n is zero or an integer of 1 to 3; and the symbol ..... represents a single or double bond; may be prepared by a process comprising reacting a compound of formula II: STR2 in which L is a leaving group and R4 is hydrogen or a carboxy protecting group, with a compound of formula III; to obtain a compound of formula IV; STR3 which is then cyclized to obtain a compound of formula V; STR4 which is reacted with a compound of formula VI;