179872-38-9Relevant articles and documents
(S)-4-amino-5-chloro-3-iodo-2-methoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)b enzamide (TRIZAC), a high-affinity ligand for the 5-HT-3 receptor
De Paulis, Tomas,Trivedi, Bakula L.,Zhang, Zhang-Jin,Schmidt, Dennis E.,Ebert, Michael H.,Hewlett, William A.
, p. 2657 - 2662 (2007/10/03)
TRIZAC is one of the most potent 5-HT-3 receptor antagonist reported to date, having 20-fold higher affinity than (S)-5-iodozacopride. This high affinity (K(i) 0.05 ± 0.01 nM) and a moderate apparent lipophilicity (log P(app) 2.12) makes TRIZAC a promising ligand for studying 5-HT-3 receptors.