143878-85-7

Basic information

• Product Name: 1H-Pyrrole-3-carboxylic acid, 4,5-dihydro-2-methyl-1-(1-phenylethyl)-, methyl ester, (S)-
• CAS NO: 143878-85-7
• Molecular Formula: C15H19NO2
• Molecular Weight: 245.321
• Mol File: 143878-85-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-3-carboxylic acid, 4,5-dihydro-2-methyl-1-(1-phenylethyl)-, methyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-3-carboxylic acid, 4,5-dihydro-2-methyl-1-(1-phenylethyl)-, methyl ester, (S)-(143878-85-7)
• EPA Substance Registry System: 1H-Pyrrole-3-carboxylic acid, 4,5-dihydro-2-methyl-1-(1-phenylethyl)-, methyl ester, (S)-(143878-85-7)

Safety Data

• Hazardous Substances Data: 143878-85-7(Hazardous Substances Data)

Usage

Molecular structure

1H-Pyrrole-3-carboxylic acid, 4,5-dihydro-2-methyl-1-(1-phenylethyl)-, methyl ester, (S)is a complex organic molecule that consists of a pyrrole ring, a carboxylic acid group, a methyl ester group, and a 2-methyl-1-(1-phenylethyl)moiety.

Methyl ester derivative

The compound is a methyl ester derivative of 1H-pyrrole-3-carboxylic acid, which means that the carboxylic acid group is esterified with a methyl group.

4,5-Dihydro-2-methyl-1-(1-phenylethyl)moiety

The compound contains a 4,5-dihydro-2-methyl-1-(1-phenylethyl)moiety, which is a five-carbon ring structure with a methyl group and a phenyl group attached to it.

Chiral center

The compound has a chiral center denoted by the (S)configuration, which means that the compound has a non-superimposable mirror image.

Pharmaceutical or biological activity

Given the presence of the pyrrole ring and the chiral center, the compound may have potential pharmaceutical or biological activity.

Medicinal chemistry research

The compound could be used in medicinal chemistry research for the development of new drugs or as a reference compound for analytical purposes.

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 38806-09-6 1-acetylcyclopropanecarboxylic acid methyl ester 
• 143955-12-8 methyl 2-acetylcyclopropanecarboxylate 

Downstream Products

• 664364-34-5 (2S,3S)-1-[(tert-butoxy)carbonyl]-2-methylpyrrolidine-3-carboxylic acid 
• 143878-86-8 (2S,3S)-<1-(1(S)-phenylethyl)-2-methylpyrrolidin-3-yl>carboxylic acid methyl ester 
• 143878-87-9 methyl (2S,3S)-2-methylpyrrolidine-3-carboxylate 
• 143878-88-0 (2R,3R)-<1-(1(S)-phenylethyl)-2-methylpyrrolidin-3-yl>carboxylic acid methyl ester 

Relevant articles and documents

NOVEL COMPOUNDS

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.

FUSED BENZENE DERIVATIVE AND USE

The present invention provides a compound represented by the general formula: [wherein Ring A represents an optionally substituted 5- to 8-membered ring, Ring B represents a further optionally substituted 4- to 10-membered ring, Ring C represents a further optionally substituted benzene ring, X1 represents carbon atom, X2 represents a carbon atom, an oxygen atom, etc., W represents a nitrogen atom, etc., Y11 represents a group represented by the formula CR2R3' (wherein R2 represents a hydrogen atom, a cyano group, a nitro group, etc., and R3' represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), Y21 represents a group represented by the formula CR4R5' (wherein R4 represents a hydrogen atom, a cyano group, a nitro group, etc., and R5' represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), etc., and R1 represents an electron-withdrawing group, respectively. The formula represents a single bond or a double bond] or a salt thereof, which is useful as an androgen receptor modulator.

Asymmetric Synthesis with Chiral Hydrogenolysable Amines. Cyclic β-Enamino Ester Reduction - A Diastereoselective Route to 2,3-Disubstituted Pyrrolidines

Cyclic β-enamino esters prepared from chiral α-methylbenzylamines are catalytically reduced with high a diastereoisomeric excess.