143878-87-9

Basic information

• Product Name: 3-Pyrrolidinecarboxylicacid,2-methyl-,methylester,(2S-cis)-(9CI)
• Synonyms: 3-Pyrrolidinecarboxylicacid,2-methyl-,methylester,(2S-cis)-(9CI)
• CAS NO: 143878-87-9
• Molecular Formula: C7H13NO2
• Molecular Weight: 143.18
• Product Categories: CARBOXYLICESTER
• Mol File: 143878-87-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 182.5±33.0 °C(Predicted)
• Appearance: /
• Density: 1.005±0.06 g/cm3(Predicted)
• PKA: 9.85±0.10(Predicted)
• CAS DataBase Reference: 3-Pyrrolidinecarboxylicacid,2-methyl-,methylester,(2S-cis)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyrrolidinecarboxylicacid,2-methyl-,methylester,(2S-cis)-(9CI)(143878-87-9)
• EPA Substance Registry System: 3-Pyrrolidinecarboxylicacid,2-methyl-,methylester,(2S-cis)-(9CI)(143878-87-9)

Safety Data

• Hazardous Substances Data: 143878-87-9(Hazardous Substances Data)

Upstream product

• 143878-86-8 (2S,3S)-<1-(1(S)-phenylethyl)-2-methylpyrrolidin-3-yl>carboxylic acid methyl ester 
• 143955-12-8 methyl 2-acetylcyclopropanecarboxylate 
• 143878-85-7 1-(1(S)-phenylethyl)-2-methyl-4,5-dihydropyrrole-3-carboxylic acid methyl ester 
• 105-45-3 acetoacetic acid methyl ester 
• 38806-09-6 1-acetylcyclopropanecarboxylic acid methyl ester 

Downstream Products

• 664364-34-5 (2S,3S)-1-[(tert-butoxy)carbonyl]-2-methylpyrrolidine-3-carboxylic acid 

Relevant articles and documents

NOVEL COMPOUNDS

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.

FUSED BENZENE DERIVATIVE AND USE

The present invention provides a compound represented by the general formula: [wherein Ring A represents an optionally substituted 5- to 8-membered ring, Ring B represents a further optionally substituted 4- to 10-membered ring, Ring C represents a further optionally substituted benzene ring, X1 represents carbon atom, X2 represents a carbon atom, an oxygen atom, etc., W represents a nitrogen atom, etc., Y11 represents a group represented by the formula CR2R3' (wherein R2 represents a hydrogen atom, a cyano group, a nitro group, etc., and R3' represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), Y21 represents a group represented by the formula CR4R5' (wherein R4 represents a hydrogen atom, a cyano group, a nitro group, etc., and R5' represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), etc., and R1 represents an electron-withdrawing group, respectively. The formula represents a single bond or a double bond] or a salt thereof, which is useful as an androgen receptor modulator.