1438881-27-6Relevant articles and documents
Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes
Kjaeaer, Svend,Linch, Mark,Purkiss, Andrew,Kostelecky, Brenda,Knowles, Phillip P.,Rosse, Carine,Riou, Philippe,Soudy, Christelle,Kaye, Sarah,Patel, Bhavisha,Soriano, Erika,Murray-Rust, Judith,Barton, Caroline,Dillon, Christian,Roffey, Jon,Parker, Peter J.,Mcdonald, Neil Q.
, p. 329 - 342 (2013)
The aPKC [atypical PKC (protein kinase C)] isoforms ? and ζ play crucial roles in the formation and maintenance of cell polarity and represent attractive anti-oncogenic drug targets in Ras-dependent tumours. To date, few isoform-specific chemical biology