144080-41-1

Basic information

• Product Name: 3-(4-chlorophenyl)-1-(thiophen-3-yl)prop-2-en-1-one
• Synonyms: 3-(4-chlorophenyl)-1-(thiophen-3-yl)prop-2-en-1-one
• CAS NO: 144080-41-1
• Molecular Weight: 248.733
• Mol File: 144080-41-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-(4-chlorophenyl)-1-(thiophen-3-yl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chlorophenyl)-1-(thiophen-3-yl)prop-2-en-1-one(144080-41-1)
• EPA Substance Registry System: 3-(4-chlorophenyl)-1-(thiophen-3-yl)prop-2-en-1-one(144080-41-1)

Safety Data

• Hazardous Substances Data: 144080-41-1(Hazardous Substances Data)

Upstream product

• 1468-83-3 1-(thiophen-3-yl)-ethanone 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 1245504-93-1 diethyl 2-(1-(4-chlorophenyl)-3-oxo-3-(thiophen-3-yl)propyl)malonate 
• 1205545-68-1 ethyl 6-(4-chlorophenyl)-2-oxo-4-(thiophen-3-yl)cyclohex-3-enecarboxylate 
• 1574828-48-0 2-(1-(4-chlorophenyl)-3-oxo-3-(thiophen-3-yl)propyl)cyclopentanone 
• 1574828-57-1 4-(4-chlorophenyl)-2-(thiophen-3-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine 
• 1373257-65-8 3-(4-chlorophenyl)-3-(phenylthio)-1-(thiophen-3-yl)propan-1-one 
• 1058062-00-2 4-(4-chlorophenyl)-2-(thiophen-3-yl)quinoline 
• 1058062-93-3 4-(4-chlorophenyl)-2-(thiophen-3-yl)-7-(trifluoromethyl)quinoline 
• 1058062-83-1 4-(4-chlorophenyl)-6-(propan-2-yl)-2-(thiophen-3-yl)quinoline 

Relevant articles and documents

Preheated fly-ash catalyzed aldol condensation: Efficient synthesis of chalcones and antimicrobial activities of some 3-thienyl chalcones

In the present study we have prepared a series of some chalcones using solvent - free Aldol - condensation by microwave irradiation. The yields of the ketones are more than 60%. The synthesised chalcones were characterized by their analytical, physical and spectral data. The antimicrobial activities of substituted styryl 3-thienyl ketones have been studied using Bauer-Kirby method.

Unexpected lactonization accompanying addition of ethyl acetoacetate to chalcones derived from 3-acetylthiophene

Chalcone derivatives containing thiophene ring were prepared by the condensation of 3-acetylthiophene with aromatic aldehydes in excellent yields. The addition of ethyl acetoacetate to chalcone derivatives 3a-3h in the presence of solid NaOH in CH2Cl2 resulted in the formation of the mixture of bicyclic lactone derivatives 5a-5h and 6-(ethoxycarbonyl) cyclohexenone derivatives 6a-6h.