1468-83-3 Usage
Description
3-Acetylthiophene, also known as 3-Acetyl-2-thiophene, is an organic compound with the chemical formula C6H4OS. It is a white to light yellow crystal powder that is characterized by its distinct chemical properties and versatile applications in various industries.
Uses
Used in Chemical Synthesis:
3-Acetylthiophene is used as a key intermediate in the synthesis of various organic compounds, such as 1-(methylthiophenylidine)-8-naphthylamine (Schiff's base) and 1-(thiophen-3-yl)ethanone. These synthesized compounds have potential applications in the development of pharmaceuticals, dyes, and other specialty chemicals.
Used in Analytical Chemistry:
3-Acetylthiophene is used as a modifier for glassy carbon electrodes in the voltammetric determination of uric acid in urine samples. This application takes advantage of its electrochemical properties to enhance the sensitivity and selectivity of the analytical method, allowing for accurate and reliable measurements in medical and diagnostic applications.
Used in Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, 3-Acetylthiophene's role as a synthetic intermediate suggests that it may also be used in the development of pharmaceuticals. The synthesized compounds, such as Schiff's bases and other derivatives, could potentially be utilized as active ingredients or components in the formulation of drugs targeting various medical conditions.
Purification Methods
Recrystallise the thiophene from pet ether (b 30-60o) or EtOH. The 2,4-dinitrophenylhydrazone crystallises from CHCl3, m 265o, and the semicarbazone crystallises from EtOH, m 174-175o. [Campaigne & Le Suer J Am Chem Soc 70 1555 1948, Beilstein 17/9 V 399.]
Check Digit Verification of cas no
The CAS Registry Mumber 1468-83-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,6 and 8 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1468-83:
(6*1)+(5*4)+(4*6)+(3*8)+(2*8)+(1*3)=93
93 % 10 = 3
So 1468-83-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H6OS/c1-5(7)6-2-3-8-4-6/h2-4H,1H3
1468-83-3Relevant articles and documents
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Campaigne,Le Suer
, p. 1555,1557 (1963)
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Method for preparing carbonyl compound through oxidative cleavage of visible light excitation aqueous solution quantum dot catalytic olefin compound
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Paragraph 0041, (2021/11/10)
The invention provides a method for preparing carbonyl compounds through oxidative cleavage of a visible light excitation aqueous solution quantum dot catalytic olefin compound. Belong to photocatalysis synthesis technical field. To the method, an aqueous solution quantum dot is used as a photocatalyst, and an aqueous solution quantum dot activated molecular oxygen catalytic oxidation aromatic alkene compound is excited by visible light to be cracked to prepare a carbonyl compound. Low-loading capacity is used, a simple aqueous solution quantum dot is used as a catalyst, the yield of the carbonyl compound is high, TON more than ten millions are obtained. The reaction conditions are mild, water serves as a main solvent for the reaction, and the carbonyl compound can be obtained by catalytic olefin compound oxidation cracking without addition of a cocatalyst or the like. The method is simple to operate, wide in substrate range and low in cost.
Redox-driven deracemization of secondary alcohols by sequential ether/O2-mediated oxidation and Ru-catalyzed asymmetric reduction
Yang, Bing,Cui, Peng,Chen, Yongsheng,Liu, Qixing,Zhou, Haifeng
supporting information, (2020/10/14)
The deracemization of benzylic alcohols has been achieved using a redox-driven one-pot two-step process. The racemic alcohols were oxidized by bis(methoxypropyl) ether and oxygen to give the ketone intermediates, followed by an asymmetric transfer hydrogenation with a chiral ruthenium catalyst. This compatible oxidation/reduction process gave the enantiomerically enriched alcohols with up to 95% ee values.