146767-44-4

Basic information

• Product Name: 3-Thienyl <(4-methylphenyl)hydrazono>methyl ketone
• Synonyms: 3-Thienyl <(4-methylphenyl)hydrazono>methyl ketone
• CAS NO: 146767-44-4
• Molecular Weight: 244.317
• Mol File: 146767-44-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-Thienyl <(4-methylphenyl)hydrazono>methyl ketone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Thienyl <(4-methylphenyl)hydrazono>methyl ketone(146767-44-4)
• EPA Substance Registry System: 3-Thienyl <(4-methylphenyl)hydrazono>methyl ketone(146767-44-4)

Safety Data

• Hazardous Substances Data: 146767-44-4(Hazardous Substances Data)

Upstream product

• 146767-34-2 4-Methylphenylazo tert-butyl sulfide 
• 1468-83-3 1-(thiophen-3-yl)-ethanone 

Relevant articles and documents

A novel approach to 1-aryl-2-(p-tolylazo)alkenes from alkyl aryl ketones

1-Aryl-2-(p-tolylazo)alkenes were synthesized starting from alkyl aryl ketones in good overall yield. The employed three-step procedure involves: i) α-p-tolylhydrazonylation of ketone enolates with tert-butyl p- tolylazosulfide 1; ii) selective reduction of the carbonyl function of the obtained α-p-tolylhydrazono ketones 3 with NaBH4; iii) dehydration of the ensuing hydrazono alcohols 4 either in an Et2O/dil. H2SO4 two-phase system or in pyridine/acetie anhydride.

α-arylation vs. α-arylhydrazonylation of alkyl aryl ketones with arylazo tert-butyl sulfides

Potassium enolates of alkyl aryl ketones react selectively in DMSO with phenylazo 1a and 4-methylphenylazo tert-butyl sulfide 1b undergoing respectively effective α-phenylation via S(RN)1 and α-(4-methylphenyl)hydrazonylation via elimination-addition.