144095-63-6

Basic information

• Product Name: 1H-Thieno[3,4-d]iMidazole-4-pentanoic acid, 1-[bis(4-Methoxyphenyl)phenylMethyl]hexahydro-2-oxo-, [3aS-(3aa,4b,6aa)]-
• Synonyms: 1H-Thieno[3,4-d]iMidazole-4-pentanoic acid, 1-[bis(4-Methoxyphenyl)phenylMethyl]hexahydro-2-oxo-, [3aS-(3aa,4b,6aa)]-;1'N-(4,4'-DiMethoxytrityl) Biotin
• CAS NO: 144095-63-6
• Molecular Formula: C₃₁H₃₄N₂O₅S
• Molecular Weight: 546.67706
• Mol File: 144095-63-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 799.6±60.0 °C(Predicted)
• Appearance: /
• Density: 1.239±0.06 g/cm3(Predicted)
• Solubility: DCM, Methanol
• PKA: 4.74±0.10(Predicted)
• BRN: 7673243
• CAS DataBase Reference: 1H-Thieno[3,4-d]iMidazole-4-pentanoic acid, 1-[bis(4-Methoxyphenyl)phenylMethyl]hexahydro-2-oxo-, [3aS-(3aa,4b,6aa)]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Thieno[3,4-d]iMidazole-4-pentanoic acid, 1-[bis(4-Methoxyphenyl)phenylMethyl]hexahydro-2-oxo-, [3aS-(3aa,4b,6aa)]-(144095-63-6)
• EPA Substance Registry System: 1H-Thieno[3,4-d]iMidazole-4-pentanoic acid, 1-[bis(4-Methoxyphenyl)phenylMethyl]hexahydro-2-oxo-, [3aS-(3aa,4b,6aa)]-(144095-63-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 144095-63-6(Hazardous Substances Data)

Usage

Description

1H-Thieno[3,4-d]iMidazole-4-pentanoic acid, 1-[bis(4-Methoxyphenyl)phenylMethyl]hexahydro-2-oxo-, [3aS-(3aa,4b,6aa)]is a complex organic compound with a unique molecular structure. It is characterized by its thienoimidazole core, which is fused with a pentanoic acid group. The molecule also features a bis(4-methoxyphenyl)phenylmethyl group and a hexahydro-2-oxo moiety, with a specific stereochemistry defined by the [3aS-(3aa,4b,6aa)] configuration. 1H-Thieno[3,4-d]iMidazole-4-pentanoic acid, 1-[bis(4-Methoxyphenyl)phenylMethyl]hexahydro-2-oxo-, [3aS-(3aa,4b,6aa)]may have potential applications in various fields due to its unique structural features and chemical properties.

Uses

Used in Pharmaceutical Industry:
1H-Thieno[3,4-d]iMidazole-4-pentanoic acid, 1-[bis(4-Methoxyphenyl)phenylMethyl]hexahydro-2-oxo-, [3aS-(3aa,4b,6aa)]is used as a key intermediate in the synthesis of novel pharmaceutical compounds. Its unique structure and functional groups make it a promising candidate for the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
In the field of chemical research, 1H-Thieno[3,4-d]iMidazole-4-pentanoic acid, 1-[bis(4-Methoxyphenyl)phenylMethyl]hexahydro-2-oxo-, [3aS-(3aa,4b,6aa)]can be used as a starting material for the synthesis of various complex organic molecules. Its unique structural features and reactivity may lead to the discovery of new chemical reactions and the development of innovative synthetic methods.
Used in Enantioselective Syntheses:
1H-Thieno[3,4-d]iMidazole-4-pentanoic acid, 1-[bis(4-Methoxyphenyl)phenylMethyl]hexahydro-2-oxo-, [3aS-(3aa,4b,6aa)]may be employed in enantioselective syntheses, where the compound's specific stereochemistry can be exploited to produce chiral molecules with high enantiomeric purity. This application is particularly relevant in the development of enantiomerically pure drugs, which can have significant advantages in terms of efficacy and safety.
Used in Material Science:
The unique structural features of 1H-Thieno[3,4-d]iMidazole-4-pentanoic acid, 1-[bis(4-Methoxyphenyl)phenylMethyl]hexahydro-2-oxo-, [3aS-(3aa,4b,6aa)]may also find applications in material science, where it could be used to develop new materials with specific properties, such as optical, electronic, or mechanical characteristics. The compound's potential use in this field would depend on further research and development to explore its properties and potential applications.

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 58-85-5 biotin 
• 122224-36-6 1-N-(4,4'-dimethoxytrithyl)-D(+)-biotin methyl ester 
• 608-16-2 biotin methyl ester 

Downstream Products

• 874889-84-6 methyl 6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoate 
• 874944-64-6 6-(1-N-(4,4'-dimethoxytrityl)-D-(+)-biotinoyl)aminohexanoic acid 
• 135137-87-0 C₄₆H₆₄N₅O₆PS 
• 135137-86-9 4,4'-dimethoxytrityl-biotinyl-6-aminohexanol 

Relevant articles and documents

Synthesis of a biotin-conjugate of phosmidosine O-ethyl ester as a G1 arrest antitumor drug

This paper deals with the synthesis of a stable biotin-phosmidosine conjugate molecule 3 that is required for isolation of biomolecules that bind to phosmidosine (1). It was found that introduction of a biotin residue into the 6-N position of phosmidosine could be carried out by reaction of an N 7-Boc-7,8-dihydro-8-oxoadenosine derivative 13 with phenyl chloroformate followed by displacement with a diamine derivative 6 along with the simultaneous removal of the Boc group and one of the two phenoxycarbonyl groups and the successive condensation with an N-tritylated biotin derivative 5. The condensation of an N-prolylphosphorodiamidite derivative 4 with an appropriately protected 7,8-dihydro-8-oxoadenosine derivative 17 having the biotin residue gave the coupling product 18, which was deprotected to give the biotin-phosmidosine (O-ethyl ester) conjugate 3.

Long-chain biotin marker and preparation method and application thereof

The invention discloses a long-chain biotin marker and a preparation method and application thereof. The long-chain biotin marker comprises a biotin molecule, a spacer arm and a reaction group. The biotin molecule comprises a ring structure and a valeric acid side chain, a structure formula (I) of the spacer arm is as shown in the specification, a structural formula (II) of the reaction group is as shown in the specification, the valeric acid side chain in the biotin molecule is connected with NH at a first tail end of the spacer arm, oxygen at a second tail end of the spacer arm is combined with phosphorus in the reaction group to form an O-P bond, and accordingly connection between the spacer arm and the reaction group is realized. The long-chain biotin marker is used for gene capturingand sequencing.