144406-93-9Relevant articles and documents
Aldose reductase inhibitors for diabetic complications: Receptor induced atom-based 3D-QSAR analysis, synthesis and biological evaluation
Vyas, Bhawna,Singh, Manjinder,Kaur, Maninder,Bahia, Malkeet Singh,Jaggi, Amteshwar Singh,Silakari, Om,Singh, Baldev
, p. 59 - 71 (2015)
Herein, atom-based 3D-QSAR analysis was performed using receptor-guided alignment of 46 flavonoid inhibitors of aldose reductase (ALR2) enzyme. 3D-QSAR models were generated in PHASE programme, and the best model corresponding to PLS factor four (QSAR4), was selected based on different statistical parameters (i.e., Rtrain2, 0.96; Qtest2 0.81; SD, 0.26). The contour plots of different structural properties generated from the selected model were utilized for the designing of five new congener molecules. These designed molecules were duly synthesized, and evaluated for their in vitro ALR2 inhibitory activity that resulted in the micromolar (IC50 22 μM) activity of all molecules. Thus, the newly designed molecules having ALR inhibitory potential could be employed for the management of diabetic complications.
Rational design for multicolor flavone-based fluorophores with aggregation-induced emission enhancement characteristics and applications in mitochondria-imaging
Liu, Liyan,Lei, Yaohui,Zhang, Jianhui,Li, Na,Zhang, Fan,Wang, Huaqiao,He, Feng
, (2018/09/14)
Fluorophores with aggregation-induced emission enhancement (AIEE) properties have attracted more attention in recent years. In order to realise more valuable applications, the different kinds of AIEE molecules are in serious need of further development. Therefore, a novel flavone-based AIEE system derived from restriction of intramolecular rotation (RIR) was designed and synthesized in this work. The results revealed that six of the compounds showed typical AIEE characteristics, with fluorescence emissions from purple, blue, cyan to green, tunable by changing substituent groups. This flavone-based AIEE system has never been reported before. The AIEE characteristics were investigated by optical spectroscopy, fluorescence photographs, scanning electron microscopy (SEM), fluorescence quantum yields (φF) and fluorescence lifetime in the CH3OH/H2O mixed solution. Moreover, benefiting from the simple structures and small molecular weight, they could permeate cells faster than current high-molecular-weight AIEE molecules. Furthermore, to examine possible biomedical applications, fluorescence imaging in living A549 lung cells and cell viabilities were examined, and the results displayed that these fluorophores showed good cellular uptake and low cytotoxicity within the experimental concentration range. In addition, these AIEE compounds possessed excellent specificity for mitochondrial targeting and mitochondrial morphological change tracking, besides, they displayed superior photostability, which indicated they are potential candidates for mitochondrial imaging.
Method for preparing 2', 4'-resacetophenone-2'-carboxylic ester
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Paragraph 0026; 0027, (2016/10/31)
The invention relates to the field of small organic molecule synthesis and particularly provides a synthetic process of 2', 4'-resacetophenone-2'-carboxylic ester. The synthetic process comprises the following steps that 1, 2', 4'-resacetophenone serves as a substrate, acyl chloride serves as acylation reagent, and 2', 4'-resacetophenone-4'-carboxylic ester is synthesized; 2, an acid binding agent with the same equivalent is added to the 2', 4'-resacetophenone-2'-carboxylic ester synthesized in step 1, and a reaction is conducted in polar non-protonic solvent at the room temperature; 3, silica gel column chromatography separation and purification are conducted, target components are collected, and the 2', 4'-resacetophenone-2'-carboxylic ester is obtained. By means of the acyl transfer reaction, the 2', 4'-resacetophenone-2'-carboxylic ester which is difficult to construct through common chemical methods can be synthesized, the reaction is high in atom economy, easy and convenient to operate and ideal in yield, and potential industrial application value is achieved.
