38256-07-4

Basic information

• Product Name: 1,3-Propanedione, 1-(2,4-dihydroxyphenyl)-3-phenyl-
• CAS NO: 38256-07-4
• Molecular Formula: C15H12O4
• Molecular Weight: 256.258
• Mol File: 38256-07-4.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 1,3-Propanedione, 1-(2,4-dihydroxyphenyl)-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Propanedione, 1-(2,4-dihydroxyphenyl)-3-phenyl-(38256-07-4)
• EPA Substance Registry System: 1,3-Propanedione, 1-(2,4-dihydroxyphenyl)-3-phenyl-(38256-07-4)

Safety Data

• Hazardous Substances Data: 38256-07-4(Hazardous Substances Data)

Upstream product

• 144406-93-9 2'-benzoyloxy-4'-hydroxyacetophenone 
• 854843-66-6 7-acetoxy-3-benzoyl-2-methyl-chromen-4-one 
• 93-58-3 benzoic acid methyl ester 
• 5706-85-4 2-hydroxy-1-(4-hydroxyphenyl)ethan-1-one 
• 98-88-4 benzoyl chloride 
• 66832-97-1 2,4-dibenzoyloxyacetophenone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 

Downstream Products

• 6665-86-7 7-hydroxyflavone 
• 113551-87-4 1-(4'-β-D-glucopyranosyloxy-2'-hydroxyphenyl)-3-phenylpropane-1,3-dione 
• 121965-40-0 1-[2'-hydroxy-4'-(2''',3''',4''',6'''-tetra-O-acetyl-β-D-glucopyranosyloxy)phenyl]-3-phenyl-propane-1,3-dione 
• 1451739-70-0 7-(pent-4-yn-1-yloxy)-2-phenyl-4H-chromen-4-one 
• 67091-11-6 2-phenyl-7-(prop-2-yn-1-yloxy)-4H-chromen-4-one 
• 119-41-5 7-ethoxycarbonylmethoxyflavone 
• 97980-65-9 2-((4-oxo-2-phenyl-4H-chromen-7-yl)oxy)acetic acid 
• 101279-20-3 3-benzoyl-4,7-dihydroxy-coumarin 

Relevant articles and documents

Identification of inhibitors targeting polyketide synthase 13 of Mycobacterium tuberculosis as antituberculosis drug leads

Polyketide synthase 13 (Pks13) is an essential enzyme in the synthesis of mycolic acids in Mtb. Therefore, Pks13 is a promising drug target for tuberculosis treatment. We used a structure-guided approach to identify novel chemotype inhibitors of Pks13 and assessed them using a Pks13 enzymatic assay and surface plasmon resonance. The structure–activity relationships (SAR) results demonstrated that the substituents at the 2, 5, and 6 positions of the 4H-chromen-4-one scaffold are critical for maintaining the MIC. Compound 6e with 2-hydroxyphenyl at the 2 position of the 4H-chromen-4-one scaffold, exhibited potent activity against Mtb H37Rv (MIC = 0.45 μg/mL) and displayed good Pks13 affinity and inhibition (IC50 = 14.3 μM). This study described here could provide an avenue to explore a novel inhibitor class for Pks13 and aid the further development of antituberculosis drugs.

Design, synthesis and biological evaluation of 2-Phenyl-4H-chromen-4-one derivatives as polyfunctional compounds against Alzheimer’s disease

Polyfunctional compounds comprise a novel class of therapeutic agents for the treatment of multi-factorial diseases. A series of 2-Phenyl-4H-chromen-4-one and its derivatives (5a–n) were designed, synthesized, and evaluated for their poly-functionality against acetylcholinestrase (AChE) and advanced glycation end products (AGEs) formation inhibitors against Alzheimer’s disease (AD). The screening results showed that most of them exhibited a significant ability to inhibit AChE AGEs formation with additional radical scavenging activity. Especially, 5m, 5b, and 5j displayed the greatest ability to inhibit AChE (IC50 = 8.0, 8.2, and 11.8 nM, respectively) and AGEs formation (IC50 = 55, 79, and 54 μM, respectively) with good antioxidant activity. Molecular docking studies explored the detailed interaction pattern with active, peripheral, and mid-gorge sites of AChE. These compounds, exhibiting such multiple pharmacological activities, can be further taken a lead for the development of potent drugs for the treatment of Alzheimer’s disease.

Five-membered heterocycle (or amide)-flavonoid compound-matrine ternary conjugate and application thereof

The invention discloses a five-membered heterocycle (or amide)-flavonoid compound-matrine ternary conjugate and application thereof. The five-membered heterocycle (or amide)-flavonoid compound-matrine ternary conjugate has a structure as shown in the specification, has an effective antibacterial activity, and has a potential application value in the aspect of antibacterial drug development. The five-membered heterocycle (or amide)-flavonoid compound-matrine ternary conjugate has a remarkable effect on the antibacterial aspect, and can be applied to prevention and treatment of MRSA, P.aeru, E.coli, Ab and other clinical common pathogens.