67091-11-6

Basic information

• Product Name: 2-phenyl-7-(prop-2-yn-1-yloxy)-4H-chromen-4-one
• Synonyms: 2-phenyl-7-(prop-2-yn-1-yloxy)-4H-chromen-4-one
• CAS NO: 67091-11-6
• Molecular Weight: 276.291
• Mol File: 67091-11-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-phenyl-7-(prop-2-yn-1-yloxy)-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-7-(prop-2-yn-1-yloxy)-4H-chromen-4-one(67091-11-6)
• EPA Substance Registry System: 2-phenyl-7-(prop-2-yn-1-yloxy)-4H-chromen-4-one(67091-11-6)

Safety Data

• Hazardous Substances Data: 67091-11-6(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 6665-86-7 7-hydroxyflavone 
• 106-96-7 propargyl bromide 
• 38256-07-4 1-(2',4'-dihydroxyphenyl)-3-phenyl-propane-1,3-dione 

Downstream Products

• 65679-20-1 9-Methylfuro<2,3-h>flavone 
• 1431847-44-7 C₁₈H₁₂O₃ 

Relevant articles and documents

Combinatorial synthesis of structurally diverse triazole-bridged flavonoid dimers and trimers

Flavonoids are a large family of compounds associated with a broad range of biologically useful properties. In recent years, synthetic compounds that contain two flavonoid units linked together have attracted attention in drug discovery and development projects. Numerous flavonoid dimer systems, incorporating a range of monomers attached via different linkers, have been reported to exhibit interesting bioactivities. From a medicinal chemistry perspective, the 1,2,3-triazole ring system has been identified as a particularly attractive linker moiety in dimeric derivatives (owing to several favourable attributes including proven biological relevance and metabolic stability) and triazole-bridged flavonoid dimers possessing anticancer and antimalarial activities have recently been reported. However, there are relatively few examples of libraries of triazole-bridged flavonoid dimers and the diversity of flavonoid subunits present within these is typically limited. Thus, this compound type arguably remains underexplored within drug discovery. Herein, we report a modular strategy for the synthesis of novel and biologically interesting triazole-bridged flavonoid heterodimers and also very rare heterotrimers from readily available starting materials. Application of this strategy has enabled step-efficient and systematic access to a library of structurally diverse compounds of this sort, with a variety of monomer units belonging to six different structural subclasses of flavonoid successfully incorporated.

Five-membered heterocycle (or amide)-flavonoid compound-matrine ternary conjugate and application thereof

The invention discloses a five-membered heterocycle (or amide)-flavonoid compound-matrine ternary conjugate and application thereof. The five-membered heterocycle (or amide)-flavonoid compound-matrine ternary conjugate has a structure as shown in the specification, has an effective antibacterial activity, and has a potential application value in the aspect of antibacterial drug development. The five-membered heterocycle (or amide)-flavonoid compound-matrine ternary conjugate has a remarkable effect on the antibacterial aspect, and can be applied to prevention and treatment of MRSA, P.aeru, E.coli, Ab and other clinical common pathogens.