1451739-70-0

Basic information

• Product Name: 7-(pent-4-yn-1-yloxy)-2-phenyl-4H-chromen-4-one
• Synonyms: 7-(pent-4-yn-1-yloxy)-2-phenyl-4H-chromen-4-one
• CAS NO: 1451739-70-0
• Molecular Weight: 304.345
• Mol File: 1451739-70-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 7-(pent-4-yn-1-yloxy)-2-phenyl-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(pent-4-yn-1-yloxy)-2-phenyl-4H-chromen-4-one(1451739-70-0)
• EPA Substance Registry System: 7-(pent-4-yn-1-yloxy)-2-phenyl-4H-chromen-4-one(1451739-70-0)

Safety Data

• Hazardous Substances Data: 1451739-70-0(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 6665-86-7 7-hydroxyflavone 
• 14267-92-6 1-chloro-4-pentyne 
• 38256-07-4 1-(2',4'-dihydroxyphenyl)-3-phenyl-propane-1,3-dione 

Downstream Products

• 1451740-55-8 7-(3-(1-(2-(2-(4-(4-oxo-4H-chromen-2-yl)-phenoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)propoxy)-2-phenyl-4H-chromen-4-one 

Relevant articles and documents

Microwave-assisted synthesis of novel bis-flavone dimers as new anticancer agents

In this study, we describe a microwave-based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized and purified in high yields. The bis-flavonoids were tested on different cell lines including HCT116, HepG2, MCF7 and MOLT-4. Several analogues showed to have anticancer activity with IC50 values in the range of 20-60 μM. Flavonoids are known for their anticancer properties and this method provides the basis for new medicinal structures.

Five-membered heterocycle (or amide)-flavonoid compound-matrine ternary conjugate and application thereof

The invention discloses a five-membered heterocycle (or amide)-flavonoid compound-matrine ternary conjugate and application thereof. The five-membered heterocycle (or amide)-flavonoid compound-matrine ternary conjugate has a structure as shown in the specification, has an effective antibacterial activity, and has a potential application value in the aspect of antibacterial drug development. The five-membered heterocycle (or amide)-flavonoid compound-matrine ternary conjugate has a remarkable effect on the antibacterial aspect, and can be applied to prevention and treatment of MRSA, P.aeru, E.coli, Ab and other clinical common pathogens.