144461-87-0

Basic information

• Product Name: 2-(1-(1-hydroxypropyl))-2-phenyl-1,3-dithiane
• Synonyms: 2-(1-(1-hydroxypropyl))-2-phenyl-1,3-dithiane
• CAS NO: 144461-87-0
• Molecular Weight: 254.417
• Mol File: 144461-87-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(1-(1-hydroxypropyl))-2-phenyl-1,3-dithiane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-(1-hydroxypropyl))-2-phenyl-1,3-dithiane(144461-87-0)
• EPA Substance Registry System: 2-(1-(1-hydroxypropyl))-2-phenyl-1,3-dithiane(144461-87-0)

Safety Data

• Hazardous Substances Data: 144461-87-0(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 5425-44-5 2-Phenyl-[1,3]dithiane 
• 123-38-6 propionaldehyde 

Downstream Products

• 131309-61-0 2-(1-(propan-1-oyl))-2-phenyl-1,3-dithiane 
• 3457-55-4 1-phenyl-1,2-butanedione 
• 1279712-76-3 (Z)-N-(1-oxo-1-phenylbut-2-en-2-yl)acetamide 
• 131309-67-6 anti-2-propanoyl-2-phenyl-1,3-dithiane 1R-oxide 

Relevant articles and documents

Photocatalytic Reductive Radical-Polar Crossover for a Base-Free Corey–Seebach Reaction

A metal-free generation of carbanion nucleophiles is of prime importance in organic synthesis. Herein we report a photocatalytic approach to the Corey–Seebach reaction. The presented method operates under mild redox-neutral and base-free conditions giving the desired product with high functional group tolerance. The reaction is enabled by the combination of photo- and hydrogen atom transfer (HAT) catalysis. This catalytic merger allows a C?H to carbanion activation by the abstraction of a hydrogen atom followed by radical reduction. The generated nucleophilic intermediate is then capable of adding to carbonyl electrophiles. The obtained dithiane can be easily converted to the valuable α-hydroxy carbonyl in a subsequent step. The proposed reaction mechanism is supported by emission quenching, radical–radical homocoupling and deuterium labeling studies as well as by calculated redox-potentials and bond strengths.

Electrophilic amination of ketone enolates mediated by the DiTOX asymmetric building block: Enantioselective formal synthesis of α-aminoacids

Diastereoselective electrophilic amination of enolates derived from 2-acyl-1,3-dithiane 1-oxides is used as the key step for an enantioselective synthesis of two α-hydrazido carboxylic acids, well-known precursors of α-amino acids. (C) 2000 Elsevier Science Ltd.

Enantioselective preparation of 2-substituted-1,3-dithiane 1-oxides using modified Sharpless sulphoxidation procedures

Enantioselective sulphoxidation of a wide range of 2-substituted-1,3-diathianes has been carried out using modified Sharpless conditions to furnish the corresponding sulphoxides in optically enriched form. Deacylation of 2-acyl-1,3-dithiane 1-oxide deriva