1446252-34-1

Basic information

• Product Name: (E)-ethyl 3-(2-(tert-butoxycarbonylamino)pyridin-4-yl)-2-(4-fluorophenyl) acrylate
• Synonyms: (E)-ethyl 3-(2-(tert-butoxycarbonylamino)pyridin-4-yl)-2-(4-fluorophenyl) acrylate
• CAS NO: 1446252-34-1
• Molecular Weight: 386.423
• Mol File: 1446252-34-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-ethyl 3-(2-(tert-butoxycarbonylamino)pyridin-4-yl)-2-(4-fluorophenyl) acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-ethyl 3-(2-(tert-butoxycarbonylamino)pyridin-4-yl)-2-(4-fluorophenyl) acrylate(1446252-34-1)
• EPA Substance Registry System: (E)-ethyl 3-(2-(tert-butoxycarbonylamino)pyridin-4-yl)-2-(4-fluorophenyl) acrylate(1446252-34-1)

Safety Data

• Hazardous Substances Data: 1446252-34-1(Hazardous Substances Data)

Upstream product

• 304873-62-9 (4-hydroxymethylpyridin-2-yl)carbamic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 639091-75-1 methyl 2-[(tert-butoxycarbonyl)amino]isonicotinate 
• 6937-03-7 methyl 2-aminoisonicotinate 
• 304873-65-2 2-[N,N-mono-(tert-butoxycarbonyl)amino]-pyridyl-4-aldehyde 
• 712-52-7 α-bromo-4-fluorobenzeneacetic acid,ethyl ester 
• 7550-03-0 ethyl 2-(4-fluorophenyl)-2-hydroxyacetate 
• 1813-94-1 ethyl 4-fluorobenzoylformate 
• 462-06-6 fluorobenzene 

Downstream Products

• 1446252-37-4 (E)-ethyl 3-(2-aminopyridine-4-yl)-2-(4-fluorophenyl)acrylate 
• 1446252-38-5 (E)-ethyl 2-(4-fluorophenyl)-3-(2-(isopropylamino)pyridin-4-yl)acrylate 
• 1446252-39-6 3-[2-(tert-butoxycarbonyl-isopropyl-amino)-pyridin-4-yl]-2-(4-fluoro-phenyl)-acrylic acid ethyl ester 

Relevant articles and documents

Azastilbenes: A cut-off to p38 MAPK inhibitors

Inhibitors with vicinal 4-fluorophenyl/4-pyridine rings on a five- or six-membered heterocyclic ring are known to inhibit the p38 mitogen-activated protein kinase (MAPK), which is a potential target for rheumatoid arthritis and several different types of cancer. Several substituted azastilbene-based compounds with vicinal 4-fluorophenyl/4-pyridine rings were designed using computational docking, synthesized, and evaluated in a cell-free radiometric p38α assay. The biochemical evaluation shows that the best inhibition (down to 110 nM) is achieved for azastilbene-based compounds having an isopropylamine substituent in the 2-position of the pyridine ring. The inhibition of p38 signaling in human breast cancer cells was observed for two of the compounds. The Royal Society of Chemistry 2013.