1446359-42-7

Basic information

• Product Name: 5-fluoro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-6-hydroxypyrimidin-4(3H)-one
• Synonyms: 5-fluoro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-6-hydroxypyrimidin-4(3H)-one
• CAS NO: 1446359-42-7
• Molecular Weight: 371.303
• Mol File: 1446359-42-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-fluoro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-6-hydroxypyrimidin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-6-hydroxypyrimidin-4(3H)-one(1446359-42-7)
• EPA Substance Registry System: 5-fluoro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-6-hydroxypyrimidin-4(3H)-one(1446359-42-7)

Safety Data

• Hazardous Substances Data: 1446359-42-7(Hazardous Substances Data)

Upstream product

• 685-88-1 fluoromalonic acid diethyl ester 
• 1354044-23-7 1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazole-3-carboximidamide 
• 1354044-05-5 1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazole-3-carboximidamide hydrochloride 
• 1446353-66-7 C₁₄H₉FN₄O 
• 1446353-53-2 C₁₄H₁₀FN₃O₃ 

Downstream Products

• 1446359-43-8 3-(3-(4,6-dichloro-5-fluoropyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazol-5-yl)isoxazole 
• 1446359-44-9 3-(3-(4-chloro-5-fluoro-6-methoxypyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazol-5-yl)isoxazole 

Relevant articles and documents

SGC STIMULATORS

Compounds of Formulae (I') and (I) are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.